4-hydroxy-2-oxoglutaric acid

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Catalysed by HOGA1mitochondrial matrix

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Catalysed by HOGA1mitochondrial matrix

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]

Catalysed by HOGA1, CLYBLmitochondrial matrix

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by HOGA1, ADHFE1mitochondrial matrix, cytosol

1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
3. Carnitine O-Palmitoyltransferase

Catalysed by HOGA1 and 1 more