Compound

3-(4-hydroxyphenyl)pyruvate

A 2-oxo monocarboxylic acid anion obtained by removal of a proton from the carboxylic acid group of 3-(4-hydroxyphenyl)pyruvic acid.

Definition from ChEBI (CHEBI:36242), read 2026-09-23. CC BY 4.0.

CHEBI:36242ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of 3-(4-hydroxyphenyl)pyruvate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C9H7O4
Mass: 179.151 g/mol
Charge: -1
InChIKey: KKADPXVIOXHVKN-UHFFFAOYSA-M
SMILES: O=C([O-])C(=O)Cc1ccc(O)cc1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

7 entities

7 entities reached.

0 reported hops7 assembled from the scaffold

MIFProteinUNIPROT:P14174substrate ofInferred only32 paths32 endpoints
MDH1ProteinUNIPROT:P40925substrate ofInferred only23 paths23 endpoints
HPDProteinUNIPROT:P32754substrate ofInferred only16 paths8 endpoints
AADATProteinUNIPROT:Q8N5Z0substrate ofInferred only10 paths10 endpoints
TATProteinUNIPROT:P17735substrate ofInferred only7 paths7 endpoints
HPDLProteinUNIPROT:Q96IR7substrate ofInferred only4 paths4 endpoints
L-tyrosineCompoundCHEBI:58315converted toInferred only2 paths2 endpoints

What the reference databases state

Chemical structure

3-(4-hydroxyphenyl)pyruvate has the functional parent pyruvateCompoundChEBI CHEBI:36242Inferred only

Statements

19 statements

19 statements · 2 reference databases · Subject: 3-(4-hydroxyphenyl)pyruvate · Sources: Human-GEM, Rhea

Order

3-(4-hydroxyphenyl)pyruvate is converted to (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoateCompoundRhea RHEA:10776Inferred only
3-(4-hydroxyphenyl)pyruvate is converted to (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoateCompoundRhea RHEA:10780Inferred only
(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate is converted to 3-(4-hydroxyphenyl)pyruvateCompoundRhea RHEA:10776Inferred only
3-(4-hydroxyphenyl)pyruvate is converted to (S)-4-hydroxymandelateCompoundRhea RHEA:21376Inferred only
CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06770Inferred only
CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06768Inferred only
CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06780Inferred only
3-(4-hydroxyphenyl)pyruvate is converted to homogentisateCompoundRhea RHEA:16189Inferred only
3-(4-hydroxyphenyl)pyruvate is converted to homogentisateCompoundHuman-GEM MAR06772Inferred only
L-tyrosine is converted to 3-(4-hydroxyphenyl)pyruvateCompoundRhea RHEA:61248Inferred only
3-(4-hydroxyphenyl)pyruvate is converted to L-tyrosineCompoundRhea RHEA:15093Inferred only
L-tyrosine is converted to 3-(4-hydroxyphenyl)pyruvateCompoundRhea RHEA:15093Inferred only

Show the remaining 7

3-(4-hydroxyphenyl)pyruvate is a substrate of AADATProteinRhea RHEA:69116Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of HPDProteinRhea RHEA:16189Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of HPDProteinHuman-GEM MAR06772Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of HPDLProteinRhea RHEA:21376Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of MDH1ProteinRhea RHEA:10780Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of MIFProteinHuman-GEM MAR06771Inferred only
3-(4-hydroxyphenyl)pyruvate is a substrate of TATProteinRhea RHEA:15093Inferred only

Reactions

30 reactions

3-(4-hydroxyphenyl)pyruvate+proton+NADH(2-)MAM01004m+NAD(+)
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR00040CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by GOT1 or GOT2 or TAT
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06768CC BY 4.0Reference data
water+dioxygen+CHEBI:178953-(4-hydroxyphenyl)pyruvate+proton+hydrogen peroxide+ammonium
Catalysed by IL4I1
Reaction pageLeft to rightBalancedEC 1.4.3.2cytosol
Human-GEM MAR06770CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvateMAM00643c
Catalysed by MIF
Reaction pageLeft to rightBalancedEC 5.3.2.1cytosol
Human-GEM MAR06771CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate+dioxygencarbon dioxide+homogentisate
Catalysed by HPD
Reaction pageLeft to rightBalancedEC 1.13.11.27cytosol
Human-GEM MAR06772CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by GOT2 or TAT
Reaction pageLeft to rightBalancedEC 2.6.1.5, 2.6.1.57, 2.6.1.1mitochondrial matrix
Human-GEM MAR06780CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate+proton3-(4-hydroxyphenyl)pyruvate+proton
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR06781CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate+proton+NADH(2-)MAM01004c+NAD(+)
Reaction pageLeft to rightBalancedEC 1.1.1.110, 1.1.1.237cytosol
Human-GEM MAR06782CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate3-(4-hydroxyphenyl)pyruvate
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR08999CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09010CC BY 4.0Reference data
(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate+NADP(3-)3-(4-hydroxyphenyl)pyruvate+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:10776CC BY 4.0Reference data
(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate+NAD(1-)3-(4-hydroxyphenyl)pyruvate+NADH(2-)+hydron
Catalysed by MDH1
Reaction pageRight to leftBalanced
Rhea RHEA:10780CC BY 4.0Reference data

Show the remaining 18

Other names

5 names

Resolves to: 3-(4-hydroxyphenyl)pyruvate

Also called: 3-(p-hydroxyphenyl)pyruvate4-HydroxyphenylpyruvateHPPp-hydroxyphenylpyruvate
Systematic name: 3-(4-hydroxyphenyl)-2-oxopropanoate