Compound
glycolate
A hydroxy monocarboxylic acid anion that is acetate where the methyl group has been hydroxylated.
Definition from ChEBI (CHEBI:29805), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C2H3O3
- Mass
- 75.043 g/mol
- Charge
- -1
- InChIKey
- AEMRFAOFKBGASW-UHFFFAOYSA-M
- SMILES
- O=C([O-])CO
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Chemical structure
- glycolate has the functional parent acetateCompoundChEBI CHEBI:29805Inferred only
Statements
31 statements
31 statements · 2 reference databases · Subject: glycolate · Sources: Human-GEM, Rhea
- glycolaldehyde is converted to glycolateCompoundHuman-GEM MAR08778Inferred only
- glycolate is converted to glycolaldehydeCompoundRhea RHEA:20001Inferred only
- glycolaldehyde is converted to glycolateCompoundRhea RHEA:20001Inferred only
- glycolaldehyde is converted to glycolateCompoundHuman-GEM MAR08775Inferred only
- glyoxylate is converted to glycolateCompoundRhea RHEA:10992Inferred only
- glycolate is converted to glyoxylateCompoundRhea RHEA:10992Inferred only
- glycolate is converted to glyoxylateCompoundRhea RHEA:18229Inferred only
- glycolate is converted to glyoxylateCompoundRhea RHEA:25311Inferred only
- glyoxylate is converted to glycolateCompoundRhea RHEA:18229Inferred only
- glyoxylic acid is converted to glycolateCompoundHuman-GEM MAR07702Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07703Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07702Inferred only
Show the remaining 19
- glyoxylic acid is converted to glycolateCompoundHuman-GEM MAR08779Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07706Inferred only
- N(2)-(1-hydroxy-2-oxoethyl)-GMP is converted to glycolateCompoundRhea RHEA:57304Inferred only
- glycolate is converted to N(2)-(1-hydroxy-2-oxoethyl)-GMPCompoundRhea RHEA:57304Inferred only
- glycolate is a substrate of GRHPRProteinHuman-GEM MAR07702Inferred only
- glycolate is a substrate of GRHPRProteinRhea RHEA:10992Inferred only
- glycolate is a substrate of HAO1ProteinHuman-GEM MAR07706Inferred only
- glycolate is a substrate of HAO1ProteinRhea RHEA:25311Inferred only
- glycolate is a substrate of HAO1ProteinHuman-GEM MAR07703Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57264Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57292Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57296Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57304Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57188Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57192Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57196Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57248Inferred only
- glycolate is a substrate of PARK7ProteinRhea RHEA:57252Inferred only
- glycolate is a substrate of PGPProteinRhea RHEA:14369Inferred only
Reactions
37 reactions
glyoxylic acid+proton+NADPH(4-)glycolate+NADP(3-)
Catalysed by GRHPR
Reaction pageReversibleBalancedEC 1.1.1.79, 1.1.1.81cytosol
Human-GEM MAR07702CC BY 4.0Reference data
glycolate+dioxygenglyoxylic acid+hydrogen peroxide
Catalysed by HAO1
Reaction pageLeft to rightBalancedEC 1.1.3.15cytosol
Human-GEM MAR07703CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR07705CC BY 4.0Reference data
FAD+glycolateFADH2+glyoxylic acid
Catalysed by HAO1
Reaction pageLeft to rightBalancedEC 1.1.3.15peroxisome
Human-GEM MAR07706CC BY 4.0Reference data
glycolaldehyde+water+NAD(+)glycolate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A2 or ALDH3A1 or ALDH3B2 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR08775CC BY 4.0Reference data
glycolaldehyde+water+NAD(+)glycolate+2proton+NADH(2-)
Catalysed by ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR08778CC BY 4.0Reference data
glyoxylic acid+proton+NADPH(4-)glycolate+NADP(3-)
Catalysed by GRHPR
Reaction pageLeft to rightBalancedEC 1.1.1.79mitochondrial matrix
Human-GEM MAR08779CC BY 4.0Reference data
MAM00675c+waterglycolate+phosphate(3-)
Catalysed by PGP
Reaction pageLeft to rightBalancedEC 3.1.3.18cytosol
Human-GEM MAR09558CC BY 4.0Reference data
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR09675CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR10360CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10436CC BY 4.0Reference data
glycolate+NADP(3-)glyoxylate+NADPH(4-)+hydron
Catalysed by GRHPR
Reaction pageDirection not assertedBalanced
Rhea RHEA:10992CC BY 4.0Reference data
Other names
1 name
Resolves to: glycolate
- Systematic name
- hydroxyacetate