N(2)-acetyl-L-ornithine

Three steps

• CHEBI:15765Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by ACY1, SLC7A6, THcytosol, extracellular spaceOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by ACY1, AMDHD2, CEMP1cytosolOne of 2 routes

• ureaReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine amidinohydrolase

  Catalysed by ACY1, GATM, ARG1cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, mitochondrial matrix

• L-cystineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

  Catalysed by ACY1, GATM, SLC7A9cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ACY1, SLC7A6, AGXT2cytosol, extracellular space, mitochondrial matrix

• iodideReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by ACY1, SLC7A6, TPOcytosol, extracellular spaceOne of 2 routes

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by ACY1, CYP17A1, AKR1C1cytosol, endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ACY1, CYP17A1cytosol, endoplasmic reticulumOne of 5 routes

• oxaloacetateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes

• nitric oxideReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by ACY1, GATM, NOS3, NOS1 and 1 morecytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by ACY1, GATM, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. PROTEIN_BS

  Catalysed by ACY1, GATMcytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by ACY1, SLC7A6, EPXcytosol, extracellular space

• CHEBI:16633Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ACY1, SLC7A6, SCLYcytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, MARS1cytosol, extracellular space

• (S)-lactateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 7 morecytosol, extracellular space

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by ACY1, SLC7A6, AADATcytosol, extracellular space

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by ACY1, SLC7A6, CNDP2cytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A7 and 5 morecytosol, extracellular spaceOne of 3 routes

• tryptamineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by ACY1, SLC7A6, DDCcytosol, extracellular space

• 2-oxoglutaramateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 5 routes

• 3-fumarylpyruvateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• CHEBI:16856Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by ACY1, GATM, GSScytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by ACY1, GATM, DAOcytosol, peroxisome

• ferrocytochrome cReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• 3-hydroxypyruvateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 4-methylumbelliferoneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by ACY1, CES2, ESD, CES1cytosol

• aceneuramateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• CHEBI:17380Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by ACY1, SLC7A6, SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Ornithine:2-oxo-acid aminotransferase
  3. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)

  Catalysed by ACY1, OAT, ALDH4A1cytosol, mitochondrial matrixOne of 4 routes

• agmatineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by ACY1, GATMcytosol, mitochondrial matrix

• AH2Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by ACY1, SLC7A6, MOCOScytosol, extracellular spaceOne of 4 routes

• S-methyl-5'-thioadenosineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by ACY1, ODC1, SRMcytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ACY1, GATM, ALAS1, ALAS2 and 1 morecytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by ACY1, SLC7A6, IL4I1cytosol, extracellular spaceOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, AARS1cytosol, extracellular space

• CHEBI:17769Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. Putrescine:oxygen oxidoreductase (deaminating)

  Catalysed by ACY1, ODC1, AOC2, AOC1 and 1 morecytosol, extracellular spaceOne of 2 routes

• trans-urocanateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by ACY1, SLC7A5, SLC7A6, HALcytosol, extracellular spaceOne of 2 routes

• urateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• 5-hydroxy-L-tryptophanReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by ACY1, SLC7A6, TPH1, TPH2cytosol, extracellular space

• 4-methyl-2-oxopentanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by ACY1, SLC7A6, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 4 routes

• all-trans-retinalReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A7cytosol, extracellular space

• CHEBI:17927Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by ACY1, GATM, SLC3A2, SLC7A6cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by ACY1, SLC7A6, GOT2, TATcytosol, extracellular space, mitochondrial matrixOne of 5 routes

• 4-fumarylacetoacetateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A6 and 3 morecytosol, extracellular space

• dTDPReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• CHEBI:18095Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by ACY1, SLC7A6, SLC1A4cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ACY1, GATM, GARTcytosol