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Proteins/UNIPROT:P05093
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..
Function from UniProtKB (P05093), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
70 statements
70 statements · 8 reference databases · Subject: CYP17A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
29 reactions
MAM00592c+proton+NADPH(4-)+dioxygen(20R)-17alpha,20-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.19cytosol
Human-GEM MAR01933CC BY 4.0Reference data
8 names
Resolves to: CYP17A1
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.19cytosol
Human-GEM MAR01944CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+pregnenolone17alpha-hydroxypregnenolone+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.19endoplasmic reticulum
Human-GEM MAR01945CC BY 4.0Reference data
17alpha-hydroxypregnenolone+2proton+2NADPH(4-)+dioxygenacetaldehyde+3beta-hydroxyandrost-5-en-17-one+2water+2NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.32cytosol
Human-GEM MAR01958CC BY 4.0Reference data
17alpha-hydroxypregnenolone+NADPH(4-)+dioxygenacetate+3beta-hydroxyandrost-5-en-17-one+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.99.-cytosol
Human-GEM MAR01959CC BY 4.0Reference data
17alpha-hydroxypregnenolone+NADPH(4-)+dioxygenacetate+3beta-hydroxyandrost-5-en-17-one+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageReversibleBalancedEC 1.14.99.-endoplasmic reticulum
Human-GEM MAR01960CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+progesterone17alpha-hydroxyprogesterone+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.19cytosol
Human-GEM MAR01981CC BY 4.0Reference data
17alpha-hydroxyprogesterone+NADPH(4-)+dioxygenandrost-4-ene-3,17-dione+acetate+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.99.-cytosol
Human-GEM MAR01985CC BY 4.0Reference data
17alpha-hydroxyprogesterone+NADPH(4-)+dioxygenandrost-4-ene-3,17-dione+acetate+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageReversibleBalancedEC 1.14.99.-endoplasmic reticulum
Human-GEM MAR01987CC BY 4.0Reference data
MAM00603c+water+NADP(3-)11beta-hydroxyprogesterone+proton+NADPH(4-)+dioxygen
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.19cytosol
Human-GEM MAR01991CC BY 4.0Reference data
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2 or BCO2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.14.19cytosol
Human-GEM MAR01999CC BY 4.0Reference data
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.99.-mitochondrial matrix
Human-GEM MAR02000CC BY 4.0Reference data