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Proteins/UNIPROT:O15382
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes (By similarity). Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (By similarity). May also function as a transporter of branched chain alpha-keto acids (By similarity)..
Function from UniProtKB (O15382), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · substrate of
3 compounds
3 compounds.
0 reported routes3 assembled routes
1 row
83 statements
83 statements · 9 reference databases · Subject: BCAT2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
2-oxoglutarate(2-)+L-valine3-methyl-2-oxobutanoate+L-glutamate(1-)
Catalysed by BCAT2
Reaction pageLeft to rightBalancedEC 2.6.1.42mitochondrial matrix
Human-GEM MAR03744CC BY 4.0Reference data
2-oxoglutarate(2-)+L-leucine4-methyl-2-oxopentanoate+L-glutamate(1-)
Catalysed by BCAT2
Reaction pageLeft to rightBalancedEC 2.6.1.42, 2.6.1.6mitochondrial matrix
6 names
Resolves to: BCAT2
A verified finding names this conversionInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
2-oxoglutarate(2-)+L-isoleucine3-methyl-2-oxovaleric acid+L-glutamate(1-)
Catalysed by BCAT2
Reaction pageLeft to rightBalancedEC 2.6.1.42mitochondrial matrix
Human-GEM MAR03778CC BY 4.0Reference data
L-leucine+2-oxoglutarate(2-)4-methyl-2-oxopentanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:18321CC BY 4.0Reference data
A verified finding names this conversionInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
L-isoleucine+2-oxoglutarate(2-)(S)-3-methyl-2-oxopentanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:24801CC BY 4.0Reference data
L-valine+2-oxoglutarate(2-)3-methyl-2-oxobutanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:24813CC BY 4.0Reference data