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Proteins/UNIPROT:O00748
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins..
Function from UniProtKB (O00748), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
105 statements
105 statements · 7 reference databases · Subject: CES2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
5 names
Resolves to: CES2
Human-GEM MAR06636CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES5A or CES3 or CES2 or CES1
Reaction pageLeft to rightBalancedEC 3.1.1.1, 3.1.1.84, 3.1.1.56cytosol
Human-GEM MAR08643CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES2
Reaction pageLeft to rightBalancedEC 3.1.1.84endoplasmic reticulum
Human-GEM MAR08645CC BY 4.0Reference data
4-methylumbelliferyl acetate+water4-methylumbelliferone+acetate+hydron
Catalysed by CES2 or ESD or CES1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12208CC BY 4.0Reference data
a carboxylic ester+wateran alcohol+a carboxylate+hydron
Catalysed by CES2 or CES1 or CES5A or CES3 or OVCA2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21164CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
cocaine+waterecgonine methyl ester+benzoic acid+hydron
Catalysed by CES2
Reaction pageDirection not assertedBalanced
Rhea RHEA:27506CC BY 4.0Reference data
prostaglandin E2 1-glyceryl ester+waterprostaglandin E2+glycerol+hydron
Catalysed by CES2 or LYPLA2 or CES1 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:48296CC BY 4.0Reference data
prostaglandin F2alpha 1-glyceryl ester+waterprostaglandin F2alpha+glycerol+hydron
Catalysed by CES2 or CES1 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:48300CC BY 4.0Reference data