(17R,20S)-17,20-dihydroxypregn-4-en-3-one

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase

Catalysed by AKR1C3cytosolOne of 2 routes

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by AKR1C3, CYP17A1cytosol, endoplasmic reticulum

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by AKR1C3, CYP17A1cytosolOne of 5 routes

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by AKR1C3, CYP21A2cytosolOne of 3 routes

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by AKR1C3, CYP17A1cytosolOne of 4 routes

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1C3, CYP17A1cytosol

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)
3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

Catalysed by AKR1C3, CYP17A1, SLC16A4, SLC16A5 and 2 morecytosol, extracellular spaceOne of 2 routes

1. 17alpha,20alpha-Dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase
2. cytochrome P450 (17alpha-hydroxyprogesterone)
3. N-acetylcadaverine + H2O = cadaverine + acetate