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Proteins/UNIPROT:P23141
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile..
Function from UniProtKB (P23141), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
999 statements
999 statements · 8 reference databases · Subject: CES1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
9 reactions
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
20 names
Resolves to: CES1
Human-GEM MAR06636CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES5A or CES3 or CES2 or CES1
Reaction pageLeft to rightBalancedEC 3.1.1.1, 3.1.1.84, 3.1.1.56cytosol
Human-GEM MAR08643CC BY 4.0Reference data
4-methylumbelliferyl acetate+water4-methylumbelliferone+acetate+hydron
Catalysed by CES2 or ESD or CES1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12208CC BY 4.0Reference data
a carboxylic ester+wateran alcohol+a carboxylate+hydron
Catalysed by CES2 or CES1 or CES5A or CES3 or OVCA2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21164CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
cholesteryl (9Z-octadecenoate)+watercholesterol+(9Z)-octadecenoate+hydron
Catalysed by CEL or CES1 or LIPA or LIPE or NCEH1
Reaction pageLeft to rightBalanced
Rhea RHEA:33875CC BY 4.0Reference data
a cholesterol ester+watercholesterol+a fatty acid+hydron
Catalysed by CES1 or LIPN or NCEH1 or LDAH
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36403CC BY 4.0Reference data
prostaglandin E2 1-glyceryl ester+waterprostaglandin E2+glycerol+hydron
Catalysed by CES2 or LYPLA2 or CES1 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:48296CC BY 4.0Reference data
prostaglandin F2alpha 1-glyceryl ester+waterprostaglandin F2alpha+glycerol+hydron
Catalysed by CES2 or CES1 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:48300CC BY 4.0Reference data