hydrogen sulfide

Three steps

• CHEBI:30249Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by CBS, SLC7A5, IDO1, TDO2 and 1 morecytosol, extracellular space

• formic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by CBS, CTH, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 5 routes

• propionic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by CBS, CTH, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by TSTD1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 10 routes

• butyric acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by CBS, CTH, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• orotateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SQOR, CYC1, UQCRFS1, DHODHouter side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. L-Serine:pyruvate aminotransferase

  Catalysed by CBS, CTH, AGXTcytosolOne of 2 routes

• (indol-3-yl)acetateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SOD1, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by TSTD1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• glutarateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by TSTD1, ABCC4, SLC22A24inner side of the membrane, outer side of the membraneOne of 12 routes

• pentanoateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SOD1, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. cystine to cysteine conversion
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by CBScytosol, extracellular spaceOne of 4 routes

• nicotinateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by TSTD1, SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane

• L-lysineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by CBS, SLC7A9, SLC3A1, SLC7A7cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by CBS, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by CBS, SLC7A6, SLC3A2, SLC7A7cytosol, extracellular spaceOne of 4 routes

• D-arginineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by CBS, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by TSTD1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. (S)-dihydroorotate + a quinone = orotate + a quinol
  3. (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)

  Catalysed by SQOR, DHODH, CADOne of 2 routes

• 3-oxopropanoateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CBS, CTH, AGXT2cytosol

• a carboxylic esterReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

  Catalysed by TSTD1, CP, PRDX6, CES2 and 4 more

• methylarsonateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by TSTD1, GSTO1, GSTO2One of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by CBS, SLC7A5, IL4I1cytosol, extracellular space

• tetra-mu3-sulfido-tetrairon(2+)Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. De novo synthesis of 2Fe2S
  3. Synthesis of 4Fe4S from 2Fe2S

  Catalysed by CBS, NDUFAB1, FDXR, FXN and 10 morecytosol, mitochondrial matrix

• a phenolReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SOD1, ARSL, ARSF, ARSK and 3 more

• serotoninReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. cystine to cysteine conversion
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by CBS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by CBS, SLC7A5, BCAT2, BCAT1cytosol, extracellular space

• D-cysteineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by CBS, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. D-serine = pyruvate + NH4(+)

  Catalysed by CBS, CTH, SRRcytosolOne of 11 routes

• 5-aminolevulinateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 2 morecytosol, extracellular space

• a hydroperoxideReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O

  Catalysed by TSTD1, CP, PRDX6, PRDX5 and 4 more

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by CBS, SLC7A5, BCAT1cytosol, extracellular spaceOne of 2 routes

• chenodeoxycholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by TSTD1, PTGES, LANCL1, GSTM4 and 3 moreextracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by CBS, SLC7A5, GOT2, GOT1 and 1 morecytosol, extracellular spaceOne of 3 routes

• glycochenodeoxycholic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular spaceOne of 12 routes

• glycolithocholic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular spaceOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by CBS, CTH, LDHDcytosolOne of 3 routes

• (S)-lactic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by CBS, CTH, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 6 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SOD1, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 2-iminopropanoateReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CBS, CTH, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. pyruvate kinase (dTDP)

  Catalysed by CBS, CTH, PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by CBS, CTH, NPLcytosol

• Cu(+)Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2 and 1 moreinner side of the membrane, outer side of the membrane

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SOD1, SLC4A1, ALDH9A1extracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by CBS, SLC7A5, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8 and 2 morecytosol, extracellular space, mitochondrial matrix

• taurineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CBS, NAGS, BAATcytosol, mitochondrial matrixOne of 4 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. cystine to cysteine conversion
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by CBS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes