chenodeoxycholate

1. Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by CYP3A4cytosol

1. solute carrier organic anion transporter (chenodiol)

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

1. chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Catalysed by UGT2A2, UGT1A3

1. a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)

Catalysed by GBA2One of 2 routes

1. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

Catalysed by GBA2

1. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SULT2A1

1. chenodeoxycholate:CoA ligase (AMP-forming)

Catalysed by SLC27A5cytosolOne of 3 routes

1. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP8B1

1. chenodeoxycholate + ATP + CoA = chenodeoxycholoyl-CoA + AMP + diphosphate

Catalysed by SLC27A5

1. chenodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

Catalysed by HSD17B10

1. chenodeoxycholate:CoA ligase (AMP-forming)
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SLC27A5, BAATcytosol, peroxisomeOne of 8 routes

1. solute carrier organic anion transporter (chenodiol)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes