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Proteins/UNIPROT:P30044
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events..
Function from UniProtKB (P30044), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
312 statements
312 statements · 7 reference databases · Subject: PRDX5 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Rhea, WikiPathways · Rows fetched: 300
4 reactions
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
12 names
Resolves to: PRDX5
Human-GEM MAR04116CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29extracellular space
Human-GEM MAR04120CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29mitochondrial matrix
Human-GEM MAR04121CC BY 4.0Reference data
a hydroperoxide+[thioredoxin]-dithiolan alcohol+[thioredoxin]-disulfide+water
Catalysed by PRDX5 or PRDX3 or PRDX2 or PRDX1 or PRDX4
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62620CC BY 4.0Reference data