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tetra-mu3-sulfido-tetrairon(2+)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

458 compounds within 3 steps: 3 in 1, 44 in 2, 411 in 3

Does it reach a compound?

One step

iron(2+)Reach from here →
1. lipoyl synthase
Catalysed by LIAS, FDX1, FDXR, GCSH and 3 moremitochondrial matrix
hydrogen sulfideReach from here →
1. lipoyl synthase
Catalysed by LIAS, FDX1, FDXR, GCSH and 3 moremitochondrial matrix
L-methionineReach from here →
1. lipoyl synthase
Catalysed by LIAS, FDX1, FDXR, GCSH and 3 moremitochondrial matrix

Two steps

CHEBI:1146900Reach from here →
1. lipoyl synthase
2. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix
L-leucineReach from here →
1. lipoyl synthase
2. transport of leucine and methionine (cytosol to extracellular)
Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

Three steps

beta-carbolineReach from here →
Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by and 7 more

Page 1 of 10

One of 6 routes

CHEBI:15699Reach from here →

lipoyl synthase
transport of homoserine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

CHEBI:15971Reach from here →

lipoyl synthase
transport of histidine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

methanethiolReach from here →

lipoyl synthase
methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

sulfateReach from here →

lipoyl synthase
hydrogen sulfide + 2 O2 = sulfate + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

L-citrullineReach from here →

lipoyl synthase
transport of citrulline and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-valineReach from here →

lipoyl synthase
transport of methionine and valine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

L-arginineReach from here →

lipoyl synthase
transport of arginine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

protein polypeptide chainReach from here →

lipoyl synthase
PROTEIN_BS

Catalysed by LIAS, FDX1, FDXR, GCSH and 3 moremitochondrial matrix, cytosol

Met-tRNA(Met)Reach from here →

lipoyl synthase
L-Methionine:tRNAMet ligase (AMP-forming)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosol

4-methylsulfanyl-2-oxobutanoateReach from here →

lipoyl synthase
glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

CHEBI:16857Reach from here →

lipoyl synthase
transport of methionine and threonine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

L-isoleucineReach from here →

lipoyl synthase
transport of isoleucine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

CHEBI:17203Reach from here →

lipoyl synthase
transport of methionine and proline (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

AH2Reach from here →

lipoyl synthase
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 3 routes

L-cysteineReach from here →

lipoyl synthase
L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 7 routes

CHEBI:17895Reach from here →

lipoyl synthase
transport of methionine and tyrosine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

CHEBI:18019Reach from here →

lipoyl synthase
transport of lysine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-glutamineReach from here →

lipoyl synthase
transport of glutamine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

S-methylmercury-L-cysteineReach from here →

lipoyl synthase
S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

a quinolReach from here →

lipoyl synthase
a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

Fe(3+)Reach from here →

lipoyl synthase
Fe(II):oxygen oxidoreductase

Catalysed by LIAS, FDX1, FDXR, GCSH and 8 moremitochondrial matrix, extracellular spaceOne of 3 routes

a thiolReach from here →

lipoyl synthase
L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

chlorine(.)Reach from here →

lipoyl synthase
transport of chloride and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-aspartateReach from here →

lipoyl synthase
L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

thiosulfateReach from here →

lipoyl synthase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 2 routes

4-methylthio-2-oxobutanoic acidReach from here →

lipoyl synthase
L-Methionine:oxygen oxidoreductase (deaminating)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosol

di-mu-sulfido-diiron(2+)Reach from here →

lipoyl synthase
De novo synthesis of 2Fe2S

Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix

L-ornithineReach from here →

lipoyl synthase
transport of methionine and ornithine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

glycineReach from here →

lipoyl synthase
transport of glycine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

2-oxo-3-sulfanylpropanoateReach from here →

lipoyl synthase
2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

L-tryptophanReach from here →

lipoyl synthase
transport of methionine and tryptophan (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

glutathioneReach from here →

lipoyl synthase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

L-alanineReach from here →

lipoyl synthase
De novo synthesis of 2Fe2S

Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrixOne of 8 routes

L-asparagineReach from here →

lipoyl synthase
transport of asparagine and methionine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

L-phenylalanineReach from here →

lipoyl synthase
transport of methionine and phenylalanine (cytosol to extracellular)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

L-homocysteineReach from here →

lipoyl synthase
S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

S-methyl-L-methionineReach from here →

lipoyl synthase
S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

L-methionine (S)-S-oxideReach from here →

lipoyl synthase
[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

L-methionine (R)-S-oxideReach from here →

lipoyl synthase
[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

S-sulfanylglutathioneReach from here →

lipoyl synthase
Sulfide:glutathione,quinone oxidoreductase

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 3 routes

heme bReach from here →

lipoyl synthase
Ferrochelatase, Mitochondrial

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 3 routes

ubiquinol-10Reach from here →

lipoyl synthase
ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 2 routes

mitochondrial matrix, cytosol

One of 245 routes

N(omega)-methyl-L-arginineReach from here →

lipoyl synthase
De novo synthesis of 2Fe2S
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrixOne of 4 routes