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Proteins/UNIPROT:P30041
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate..
Function from UniProtKB (P30041), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
366 statements
366 statements · 8 reference databases · Subject: PRDX6 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
35 reactions
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR00960CC BY 4.0Reference data
17 names
Resolves to: PRDX6
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9mitochondrial matrix
Human-GEM MAR00963CC BY 4.0Reference data
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+glutathione disulfide+water15(S)-HPETE+2CHEBI:16856
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR00988CC BY 4.0Reference data
12(S)-HPETEMAM02096c
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR01043CC BY 4.0Reference data
12(S)-HPETEMAM02096e
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9extracellular space
Human-GEM MAR01045CC BY 4.0Reference data
12(S)-HPETEMAM02096x
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9peroxisome
Human-GEM MAR01048CC BY 4.0Reference data
12(S)-HPETEMAM02096r
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9endoplasmic reticulum
Human-GEM MAR01049CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxideMAM01792c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02061CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxideMAM01792l+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02062CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxideMAM01792r+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum
Human-GEM MAR02063CC BY 4.0Reference data
MAM01000c+proton+hydrogen peroxideMAM01794c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02076CC BY 4.0Reference data
MAM01000l+proton+hydrogen peroxideMAM01794l+2water
Catalysed by MPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02077CC BY 4.0Reference data