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Proteins/UNIPROT:P35520
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)..
Function from UniProtKB (P35520), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
273 statements
273 statements · 9 reference databases · Subject: CBS · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
homocysteine+L-seryl residuewater+L,L-cystathionine
Catalysed by CBS
Reaction pageLeft to rightBalancedEC 4.2.1.22cytosol
Human-GEM MAR03879CC BY 4.0Reference data
proton+hydrogen sulfide+L-seryl residueL-cysteine+water
Catalysed by CBS
Reaction pageLeft to rightBalancedEC 4.2.1.22
2 names
Resolves to: CBS
Human-GEM MAR04323CC BY 4.0Reference data
water+CHEBI:27760Se-methylselenocysteine+L-seryl residue
Catalysed by CBS
Reaction pageLeft to rightBalancedEC 4.2.1.22cytosol
Human-GEM MAR07135CC BY 4.0Reference data
L-homocysteine+L-seryl residueL,L-cystathionine+water
Catalysed by CBS
Reaction pageDirection not assertedBalanced
Rhea RHEA:10112CC BY 4.0Reference data