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Proteins/UNIPROT:O43813
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione..
Function from UniProtKB (O43813), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
136 statements
136 statements · 4 reference databases · Subject: LANCL1 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea
2 reactions
RX+glutathionean S-substituted glutathione+a halide anion+hydron
Catalysed by GSTT4 or GSTA4 or GSTZ1 or LANCL1 or HPGDS or GSTA1 or GSTA2 or GSTP1 or GSTM1 or GSTT2 or GSTT2B or MGST1 and 11 more alternatives
4 names
Resolves to: LANCL1
Rhea RHEA:16437CC BY 4.0Reference data
1-chloro-2,4-dinitrobenzene+glutathione2,4-dinitrophenyl-S-glutathione+chloride+hydron
Catalysed by PTGES or LANCL1 or GSTM4 or MGST2
Reaction pageLeft to rightBalanced
Rhea RHEA:51220CC BY 4.0Reference data