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Proteins/UNIPROT:Q9UM01
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine. Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity)..
Function from UniProtKB (Q9UM01), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 7 · transported by
7 compounds
7 compounds.
0 reported routes7 assembled routes
1 row
94 statements
94 statements · 7 reference databases · Subject: SLC7A7 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
27 reactions
Transported by SLC3A2 & SLC7A8 or SLC7A2 or SLC7A5 or SLC36A1 or SLC7A7 or SLC7A3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05070CC BY 4.0Reference data
6 names
Resolves to: SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05074CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05077CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05078CC BY 4.0Reference data
L-seryl residueL-seryl residue
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05079CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05080CC BY 4.0Reference data
L-phenylalanineL-phenylalanine
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05082CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05084CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05085CC BY 4.0Reference data
Transported by SLC7A8 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05087CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05088CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05089CC BY 4.0Reference data