Loading the page.
Proteins/UNIPROT:P54687
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine..
Function from UniProtKB (P54687), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · substrate of
3 compounds
3 compounds.
0 reported routes3 assembled routes
56 statements
56 statements · 7 reference databases · Subject: BCAT1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
2-oxoglutarate(2-)+L-valine3-methyl-2-oxobutanoate+L-glutamate(1-)
Catalysed by BCAT1
Reaction pageLeft to rightBalancedEC 2.6.1.42cytosol
Human-GEM MAR03747CC BY 4.0Reference data
2-oxoglutarate(2-)+L-isoleucine3-methyl-2-oxovaleric acid+L-glutamate(1-)
Catalysed by BCAT1
Reaction pageLeft to rightBalancedEC 2.6.1.42cytosol
3 names
Resolves to: BCAT1
2-oxoglutarate(2-)+L-leucine4-methyl-2-oxopentanoate+L-glutamate(1-)
Catalysed by BCAT1
Reaction pageLeft to rightBalancedEC 2.6.1.42, 2.6.1.6cytosol
Human-GEM MAR06923CC BY 4.0Reference data
A verified finding names this conversionInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
L-leucine+2-oxoglutarate(2-)4-methyl-2-oxopentanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:18321CC BY 4.0Reference data
A verified finding names this conversionInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
L-isoleucine+2-oxoglutarate(2-)(S)-3-methyl-2-oxopentanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:24801CC BY 4.0Reference data
L-valine+2-oxoglutarate(2-)3-methyl-2-oxobutanoate+L-glutamate(1-)
Reaction pageLeft to rightBalanced
Rhea RHEA:24813CC BY 4.0Reference data