What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- FDX1ProteinUNIPROT:P10109substrate ofInferred only22 paths22 endpoints
- FDXRProteinUNIPROT:P22570substrate ofInferred only18 paths18 endpoints
- GCSHProteinUNIPROT:P23434substrate ofInferred only11 paths11 endpoints
- NFU1ProteinUNIPROT:Q9UMS0substrate ofInferred only6 paths6 endpoints
- ISCA2ProteinUNIPROT:Q86U28substrate ofInferred only5 paths5 endpoints
- ISCA1ProteinUNIPROT:Q9BUE6substrate ofInferred only5 paths5 endpoints
- LIASProteinUNIPROT:O43766substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: tetra-mu3-sulfido-tetrairon(2+) · Sources: Human-GEM
- di-mu-sulfido-diiron(2+) is converted to tetra-mu3-sulfido-tetrairon(2+)CompoundHuman-GEM MAR20184Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of FDX1ProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of FDXRProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of GCSHProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of ISCA1ProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of ISCA2ProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of LIASProteinHuman-GEM MAR06403Inferred only
- tetra-mu3-sulfido-tetrairon(2+) is a substrate of NFU1ProteinHuman-GEM MAR06403Inferred only
Reactions
2 reactions
MAM00210m+3proton+NADPH(4-)+2S-adenosyl-L-methionine+tetra-mu3-sulfido-tetrairon(2+)MAM00208m+2MAM01098m+4iron(2+)+2hydrogen sulfide+2L-methionine+NADP(3-)
Catalysed by LIAS & FDX1 & FDXR & GCSH & ISCA1 or LIAS & FDX1 & FDXR & GCSH & ISCA2 or LIAS & FDX1 & FDXR & GCSH & NFU1
Reaction pageLeft to rightBalancedEC 2.8.1.8mitochondrial matrix
Human-GEM MAR06403CC BY 4.0Reference data
2ATP+2water+NADPH(4-)+2di-mu-sulfido-diiron(2+)2ADP+3proton+NADP(3-)+2phosphate(3-)+tetra-mu3-sulfido-tetrairon(2+)
Catalysed by FDXR & HSPA9 & IBA57 & FDX2 & GLRX5 & ISCA2 & HSCB & ISCA1
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR20184CC BY 4.0Reference data
Other names
9 names
Resolves to: tetra-mu3-sulfido-tetrairon(2+)
- Also called
- [4Fe-4S](2+)[4Fe-4S]2+[Fe4(mu3-S)4](2+)[Fe4(μ3-S)4]2+[Fe4S4](2+)[Fe4S4]2+Fe4S4(2+)Fe4S42+
- Systematic name
- tetra-μ3-sulfido-tetrairon(2+)