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Proteins/UNIPROT:Q9BXI2
Mitochondrial transporter of the positively charged amino acids ornithine, lysine and arginine, and the neutral amino acid citrulline. In addition, transports the basic amino acids histidine, homoarginine, and asymmetric dimethylarginine (aDMA), but not symmetric DMA, and the D-forms of lysine, arginine, ornithine and histidine. Functions by both counter-exchange and uniport mechanisms..
Function from UniProtKB (Q9BXI2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
108 statements
108 statements · 3 reference databases · Subject: SLC25A2 · Sources: Human-GEM, Reactome, Rhea
43 reactions
L-arginine+protonL-arginine+proton
Transported by SLC25A15 or SLC25A2
Reaction pageReversibleBalancedEC 4.3.2.1cytosol, mitochondrial matrix
Human-GEM MAR00079CC BY 4.0Reference data
Transported by SLC25A15 or SLC25A2
Reaction pageReversibleBalancedEC 3.2.1.14mitochondrial matrix, cytosol
4 names
Resolves to: SLC25A2
L-citrulline+L-ornithineL-citrulline+L-ornithine
Transported by SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR02271CC BY 4.0Reference data
proton+L-ornithineproton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05105CC BY 4.0Reference data
L-arginine+proton+CHEBI:18019L-arginine+proton+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR06299CC BY 4.0Reference data
L-arginine+proton+CHEBI:18019L-arginine+proton+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR06300CC BY 4.0Reference data
proton+CHEBI:18019+L-ornithineproton+CHEBI:18019+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR06301CC BY 4.0Reference data
proton+CHEBI:18019+L-ornithineproton+CHEBI:18019+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, cytosol, mitochondrial matrix
Human-GEM MAR06302CC BY 4.0Reference data
proton+CHEBI:15971+CHEBI:18019proton+CHEBI:15971+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR06303CC BY 4.0Reference data
proton+CHEBI:15971+CHEBI:18019proton+CHEBI:15971+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR06304CC BY 4.0Reference data
L-citrulline+proton+CHEBI:18019L-citrulline+proton+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR06305CC BY 4.0Reference data
L-citrulline+proton+CHEBI:18019L-citrulline+proton+CHEBI:18019
Transported by SLC25A2
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR06306CC BY 4.0Reference data