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Proteins/UNIPROT:Q9Y226
Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions. Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption. Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate. Urate and orotate transports are Cl(-)-dependent. Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable)..
Function from UniProtKB (Q9Y226), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 4 reference databases · Subject: SLC22A13 · Sources: gene ontology, Human-GEM, Reactome, Rhea
6 reactions
proton+nicotinic acidproton+nicotinic acid
Transported by SLC22A13
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07154CC BY 4.0Reference data
urate+(S)-lactateurate+(S)-lactate
Transported by SLC22A12 or SLC22A13
Reaction pageLeft to rightBalanced
6 names
Resolves to: SLC22A13
urate+succinate(2-)urate+succinate(2-)
Transported by SLC22A13
Reaction pageLeft to rightBalanced
Rhea RHEA:72007CC BY 4.0Reference data
urate+glutathioneurate+glutathione
Transported by SLC22A13
Reaction pageLeft to rightBalanced
Rhea RHEA:72011CC BY 4.0Reference data
nicotinate+uratenicotinate+urate
Transported by SLC22A12 or SLC22A13
Reaction pageLeft to rightBalanced
Rhea RHEA:72023CC BY 4.0Reference data
orotate+a carboxylateorotate+a carboxylate
Transported by SLC22A13
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:73487CC BY 4.0Reference data