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Proteins/UNIPROT:O14684
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGE3, though PGH2 remains the preferred substrate. Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively..
Function from UniProtKB (O14684), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
63 statements
63 statements · 9 reference databases · Subject: PTGES · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
21 reactions
CHEBI:16856+MAM02096c(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
11 names
Resolves to: PTGES
CHEBI:16856+MAM02096r(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18endoplasmic reticulum
Human-GEM MAR01053CC BY 4.0Reference data
CHEBI:16856+MAM02096x(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18peroxisome
Human-GEM MAR01054CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333m
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18mitochondrial matrix
Human-GEM MAR01120CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333r
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18endoplasmic reticulum
Human-GEM MAR01121CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333x
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18peroxisome
Human-GEM MAR01122CC BY 4.0Reference data
prostaglandin H2prostaglandin E2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageLeft to rightBalancedEC 5.3.99.3cytosol
Human-GEM MAR01312CC BY 4.0Reference data
CHEBI:16856+prostaglandin J2MAM02864c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.188, 2.5.1.18cytosol
Human-GEM MAR01367CC BY 4.0Reference data
CHEBI:16856+prostaglandin A2MAM02863c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01370CC BY 4.0Reference data
MAM01662c+CHEBI:16856MAM02860c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01379CC BY 4.0Reference data
MAM01234c+CHEBI:16856MAM02859c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01384CC BY 4.0Reference data
prostaglandin E1prostaglandin H1
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
Human-GEM MAR01394CC BY 4.0Reference data