ABCC4

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Selectively transports steroid glucuronates and sulfates. Mediates the efflux of estrogens glucuronated at C-16 and C-17 positions, but has no transporter activity toward estrogens glucuronated at C-3. Has high affinity for dehydroepiandrosterone-3-sulfate and can also transport testosterone-17-sulfate, but has no transporter activity toward androsterone and etiocholanolone sulfate conjugates. Does not transport estrone 3-sulfate. Displays low affinity and high transport velocity for folates. Transports a wide range of drugs and their metabolites. including anticancer, antiviral and antibiotic molecules. May confer resistance to anticancer agents. Can mediate the efflux of methotrexate but is inactive toward polyglutaminated methotrexate, which is the predominant intracellular form..

Function from UniProtKB (O15439), read 2026-09-23. CC BY 4.0.