chlorine(.)

Three steps

• (9Z)-octadecenoyl-CoAReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by SLC6A14, SLC27A2, ACSL3, ACSL1 and 5 moreextracellular space, cytosol, endoplasmic reticulum

• phytanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. phytanate-CoA ligase

  Catalysed by SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 5 moreextracellular space, cytosol, peroxisomeOne of 15 routes

• prostaglandin E1Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS1, PTGS2extracellular space, cytosolOne of 7 routes

• prostaglandin D2Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by SLC6A6, MTO1, TBXAS1, PTGS2 and 1 moreextracellular space, cytosolOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX5, ALOX15, ALOX12extracellular space, cytosol, endoplasmic reticulum

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX15B, ALOX15, ALOX12extracellular space, cytosol, endoplasmic reticulum

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX5extracellular space, cytosol, endoplasmic reticulum

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)

  Catalysed by SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• 5-formimidoyltetrahydrofolateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by SLC6A9, SLC6A14, SHMT1, FTCDextracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 4 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by SLC6A14, ALOX15B, ALOX15extracellular space, cytosol, endoplasmic reticulum

• (R)-S-lactoylglutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLC6A9, SLC6A14, GSS, GLO1 and 1 moreextracellular space, cytosolOne of 3 routes

• 2-oxoadipateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by SLC6A9, SLC6A14, AADATextracellular space, cytosol

• 3,5-diiodo-L-tyrosineReach from here →
  1. Transport of L-Tyrosine by Atb0 Transporter
  2. thyroid peroxidase (iodine)
  3. thyroid peroxidase (3-iodo-L-tyrosine)

  Catalysed by SLC6A14, TPOextracellular space, cytosolOne of 4 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosolOne of 4 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 5 moreextracellular space, cytosolOne of 4 routes

• beta-D-fructose 6-phosphateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by SLC6A14, GFPT2, GFPT1, GNPDA1 and 1 moreextracellular space, cytosol

• D-ornithineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by SLC6A6, GATM, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• S-formylglutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLC6A9, SLC6A14, GSS, ADH1C and 5 moreextracellular space, cytosolOne of 2 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosol

• 3',5'-cyclic GMPReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sphing-4-enineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC6A6, BAAT, ASAH1, ACER2 and 2 moreextracellular space, cytosol, peroxisome, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SLC6A6, BAAT, SAT1, SAT2extracellular space, cytosol, peroxisomeOne of 8 routes

• hypotaurineReach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2

  Catalysed by SLC6A14, CDO1, GADL1, CSADextracellular space, cytosol

• adenosine 5'-phosphoramidateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC26A6, PAPSS1, PAPSS2, FHITextracellular space, cytosol

• dimethylamineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by SLC6A9, SLC6A14, AGXT2, DDAH1extracellular space, cytosolOne of 2 routes

• L-glutamate 5-semialdehydeReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by SLC6A6, GATM, OATextracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosol

• N-phosphocreatineReach from here →
  1. Transport of Guanidinoacetic Acid
  2. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  3. creatine kinase (creatine)

  Catalysed by GAMT, CKM, CKB, CKMT1A and 1 moreextracellular space, cytosolOne of 3 routes

• porphobilinogenReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
  3. 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing

  Catalysed by SLC6A9, SLC6A14, ALAS1, ALAS2 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• L,L-cystathionineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SLC6A6, BAAT, NAGSextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• 3',5'-cyclic AMPReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• phosphoethanolamineReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine acetaldehyde-lyase (glycine-forming)
  3. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate

  Catalysed by SLC6A14, ETNPPLextracellular space, cytosol

• N-acetylputrescineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosolOne of 3 routes

• 4-aminobutanalReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

  Catalysed by SLC6A14, SLC3A2, SLC7A7, AOC1extracellular space, cytosol

• glutathione disulfideReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC6A9, SLC6A14, GSS, GPX5 and 8 moreextracellular space, cytosolOne of 37 routes

• taurolithocholate 3-sulfateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. bile acid-CoA:amino acid N-acyltransferase (lithocholate)
  3. 3'-Phosphoadenylylsulfate:taurolithocholate sulfotransferase

  Catalysed by SLC6A6, BAAT, SULT2A1extracellular space, cytosolOne of 4 routes

• (S)-2-amino-6-oxohexanoateReach from here →
  1. transport of chloride and lysine (cytosol to extracellular)
  2. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
  3. L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)

  Catalysed by SLC6A14, AASSextracellular space, cytosol, mitochondrial matrix

• N(1)-acetylspermidineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

  Catalysed by SLC6A14, SLC3A2, SLC7A7, PAOXextracellular space, cytosol

• an acyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC6A6, BAAT, ASAH1, ACER2 and 2 moreextracellular space, cytosol, peroxisome, Golgi apparatusOne of 3 routes

• 3-aminopropanalReach from here →
  1. transport of chloride and lysine (cytosol to extracellular)
  2. deoxyhypusine synthase (1,3-diaminopropane)
  3. primary-amine oxidase (1,3-diaminopropane)

  Catalysed by SLC6A14, DHPS, AOC2, AOC1 and 1 moreextracellular space, cytosol

• 5-oxo-L-prolineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by SLC6A9, SLC6A14, GSS, CHAC2 and 1 moreextracellular space, cytosol

• L-2-aminopentanoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosolOne of 4 routes

• anserineReach from here →
  1. transport of beta-alanine and chloride (cytosol to extracellular)
  2. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
  3. carnosine + S-adenosyl-L-methionine = anserine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLC6A6, SLC6A14, CARNS1, CARNMT1extracellular space, cytosol