(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

128 compounds within 3 steps: 6 in 1, 13 in 2, 109 in 3

One step

(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ALOX15B
leukotriene A4Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
Catalysed by ALOX5
glutathione disulfideReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 2 more
5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O
Catalysed by CYP1A1, CYP1A2, CYP1B1, CYP2S1
7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate
Catalysed by ALOXE3
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 2 more

Two steps

AReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 moreOne of 3 routes
2,4-dinitrophenyl-S-glutathioneReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O
2. transport of leukotriene A4 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1extracellular space, cytosol

Three steps

One of 2 routes

(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

15(S)-HPETEReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 8 morecytosol

L-cystineReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 2 morecytosol

CHEBI:16856Reach from here →

Catalysed by ALOX5, SLCO2A1extracellular space, cytosolOne of 9 routes

methylarsonateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more

thiosulfateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 moreOne of 4 routes

leukotriene C4Reach from here →

Catalysed by ALOX5, LTC4ScytosolOne of 3 routes

(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

tauroursodeoxycholateReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

glycoursodeoxycholateReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 8 morecytosolOne of 2 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by ALOX5, SLCO2A1, PTGES, MGST3 and 19 moreextracellular space, cytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin B1Reach from here →

Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes

leukotriene F4Reach from here →

Catalysed by ALOX5, LTC4ScytosolOne of 6 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 6 more

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 more

S-methyl glutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more

L-cystine-bis-glycineReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 morecytosol

S-adenosylglutathioneReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more

acetylcholineReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1B3extracellular space, cytosolOne of 4 routes

pyruvateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 morecytosol

(S)-malateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 moremitochondrial matrix, cytosolOne of 2 routes

L-leucineReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 morecytosol, extracellular space

CHEBI:15650Reach from here →

Catalysed by ALOX5, SLCO1B1extracellular space, cytosolOne of 4 routes

betaine aldehydeReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more

bromideReach from here →

Catalysed by ALOX5, SLCO2A1, MGST3, GSTA4 and 15 moreextracellular space, cytosolOne of 2 routes

a halide anionReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 25 more

sulfateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 morecytosolOne of 3 routes

lithocholic acidReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

oxaloacetateReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 4 more

L-arginineReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 morecytosol, inner side of the membrane, outer side of the membrane

formaldehydeReach from here →

Catalysed by PTGES, MGST3, GPX1, GPX2 and 5 moreOne of 3 routes