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Proteins/UNIPROT:Q06520
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity)..
Function from UniProtKB (Q06520), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
113 statements
113 statements · 7 reference databases · Subject: SULT2A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
37 reactions
chenodeoxycholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM02950c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR01729CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+taurolithocholateproton+adenosine 3',5'-bismonophosphate+taurolithocholate 3-sulfate
Catalysed by
10 names
Resolves to: SULT2A1
Reaction pageReversibleBalancedEC 2.8.2.14cytosol
Human-GEM MAR01843CC BY 4.0Reference data
glycolithocholic acid+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+glycolithocholate 3-sulfate
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR01846CC BY 4.0Reference data
MAM01196c+3'-phospho-5'-adenylyl sulfateMAM01195c+adenosine 3',5'-bismonophosphate
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR07057CC BY 4.0Reference data
17beta-hydroxy-5alpha-androstan-3-one+3'-phospho-5'-adenylyl sulfate5alpha-dihydrotestosterone sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR07974CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+testosteroneproton+adenosine 3',5'-bismonophosphate+testosterone 17-sulfate
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR07978CC BY 4.0Reference data
cholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03504c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12173CC BY 4.0Reference data
deoxycholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03538c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12197CC BY 4.0Reference data
glycocholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03587c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12236CC BY 4.0Reference data
glycochenodeoxycholic acid+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03588c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12239CC BY 4.0Reference data
glycodeoxycholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03589c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12242CC BY 4.0Reference data
glycoursodeoxycholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03637c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12245CC BY 4.0Reference data