Compound
sphing-4-enine
The cationic sphingoid resulting from the protonation of the amino group of sphingosine.
Definition from ChEBI (CHEBI:57756), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, cation
- Formula
- C18H38NO2
- Mass
- 300.507 g/mol
- Charge
- +1
- InChIKey
- WWUZIQQURGPMPG-KRWOKUGFSA-O
- SMILES
- CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H]([NH3+])CO
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
18 entities
18 entities reached.
0 reported hops18 assembled from the scaffold
- ASAH1ProteinUNIPROT:Q13510substrate ofInferred only131 paths22 endpoints
- SPHK1ProteinUNIPROT:Q9NYA1substrate ofInferred only62 paths31 endpoints
- ASAH2ProteinUNIPROT:Q9NR71substrate ofInferred only42 paths7 endpoints
- CERS2ProteinUNIPROT:Q96G23substrate ofInferred only35 paths6 endpoints
- ACER2ProteinUNIPROT:Q5QJU3substrate ofInferred only24 paths4 endpoints
- SPHK2ProteinUNIPROT:Q9NRA0substrate ofInferred only24 paths8 endpoints
- CERS1ProteinUNIPROT:P27544substrate ofInferred only16 paths8 endpoints
- CERS6ProteinUNIPROT:Q6ZMG9substrate ofInferred only16 paths8 endpoints
- CERS4ProteinUNIPROT:Q9HA82substrate ofInferred only15 paths9 endpoints
- CERS5ProteinUNIPROT:Q8N5B7substrate ofInferred only14 paths7 endpoints
- DBPProteinUNIPROT:Q10586substrate ofInferred only12 paths12 endpoints
- ACER1ProteinUNIPROT:Q8TDN7substrate ofInferred only10 paths5 endpoints
Show the remaining 6
- CERS3ProteinUNIPROT:Q8IU89substrate ofInferred only9 paths9 endpoints
- NAAAProteinUNIPROT:Q02083substrate ofInferred only6 paths3 endpoints
- ACER3ProteinUNIPROT:Q9NUN7substrate ofInferred only4 paths4 endpoints
- TLCD3BProteinUNIPROT:Q71RH2substrate ofInferred only3 paths1 endpoint
- PAFAH2ProteinUNIPROT:Q99487substrate ofInferred only2 paths2 endpoints
- FADS3ProteinUNIPROT:Q9Y5Q0substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
56 statements
56 statements · 2 reference databases · Subject: sphing-4-enine · Sources: Human-GEM, Rhea
- sphing-4-enine 1-phosphate is converted to sphing-4-enineCompoundRhea RHEA:27518Inferred only
- sphing-4-enine is converted to sphing-4-enine 1-phosphateCompoundRhea RHEA:35847Inferred only
- sphing-4-enine is converted to sphingosine 1-phosphateCompoundHuman-GEM MAR00773Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR00783Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR08235Inferred only
- sphing-4-enine is converted to sphingosine 1-phosphateCompoundHuman-GEM MAR12082Inferred only
- sphing-4-enine is a substrate of ACER1ProteinRhea RHEA:41267Inferred only
- sphing-4-enine is a substrate of ACER1ProteinRhea RHEA:41299Inferred only
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:41287Inferred only
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:41279Inferred only
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:41299Inferred only
Show the remaining 44
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:41267Inferred only
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:38891Inferred only
- sphing-4-enine is a substrate of ACER2ProteinRhea RHEA:41291Inferred only
- sphing-4-enine is a substrate of ACER3ProteinRhea RHEA:41299Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:58484Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:38891Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:41279Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:41287Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:41291Inferred only
- sphing-4-enine is a substrate of ASAH1ProteinRhea RHEA:41299Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:41279Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:41299Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:38891Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:41267Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:41291Inferred only
- sphing-4-enine is a substrate of ASAH2ProteinRhea RHEA:41287Inferred only
- sphing-4-enine is a substrate of CERS1ProteinRhea RHEA:36691Inferred only
- sphing-4-enine is a substrate of CERS1ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:37123Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:45284Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:36691Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:36687Inferred only
- sphing-4-enine is a substrate of CERS2ProteinRhea RHEA:37115Inferred only
- sphing-4-enine is a substrate of CERS3ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS4ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS4ProteinRhea RHEA:36691Inferred only
- sphing-4-enine is a substrate of CERS5ProteinRhea RHEA:36687Inferred only
- sphing-4-enine is a substrate of CERS5ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS6ProteinRhea RHEA:23768Inferred only
- sphing-4-enine is a substrate of CERS6ProteinRhea RHEA:36687Inferred only
- sphing-4-enine is a substrate of DBPProteinHuman-GEM MAR00773Inferred only
- sphing-4-enine is a substrate of FADS3ProteinRhea RHEA:76483Inferred only
- sphing-4-enine is a substrate of NAAAProteinRhea RHEA:38891Inferred only
- sphing-4-enine is a substrate of NAAAProteinRhea RHEA:41291Inferred only
- sphing-4-enine is a substrate of PAFAH2ProteinRhea RHEA:41408Inferred only
- sphing-4-enine is a substrate of SPHK1ProteinHuman-GEM MAR00773Inferred only
- sphing-4-enine is a substrate of SPHK1ProteinRhea RHEA:35847Inferred only
- sphing-4-enine is a substrate of SPHK2ProteinHuman-GEM MAR00773Inferred only
- sphing-4-enine is a substrate of SPHK2ProteinHuman-GEM MAR12082Inferred only
- sphing-4-enine is a substrate of SPHK2ProteinRhea RHEA:35847Inferred only
- sphing-4-enine is a substrate of TLCD3BProteinRhea RHEA:36687Inferred only
- sphing-4-enine is a substrate of TLCD3BProteinRhea RHEA:36691Inferred only
- sphing-4-enine is a substrate of TLCD3BProteinRhea RHEA:45284Inferred only
Reactions
57 reactions
an N-acylsphing-4-enine+CHEBI:1146900+protonsphing-4-enine+an acyl-CoA
Catalysed by ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23Golgi apparatus
Human-GEM MAR00733CC BY 4.0Reference data
an N-acylsphing-4-enine+CHEBI:1146900+protonsphing-4-enine+an acyl-CoA
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00758CC BY 4.0Reference data
ATP+sphing-4-enineADP+proton+sphingosine 1-phosphate
Catalysed by SPHK2 or DBP or SPHK1
Reaction pageLeft to rightBalancedEC 2.7.1.91cytosol
Human-GEM MAR00773CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00775CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or PLPP2 or PLPP3
Reaction pageLeft to rightBalancedEC 3.1.3.4extracellular space
Human-GEM MAR00783CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, lysosome
Human-GEM MAR00798CC BY 4.0Reference data
sphing-4-enine+CHEBI:67119proton+psychosine+UDP
Reaction pageReversibleBalancedEC 2.4.1.23cytosol
Human-GEM MAR00912CC BY 4.0Reference data
water+psychosinealpha-D-galactose+sphing-4-enine
Catalysed by GALC
Reaction pageLeft to rightBalancedEC 3.2.1.46lysosome
Human-GEM MAR00914CC BY 4.0Reference data
an N-acylsphing-4-enine+watersphing-4-enine+fatty acid
Catalysed by ASAH1
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23lysosome
Human-GEM MAR08211CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by SGPP1
Reaction pageLeft to rightBalancedEC 3.1.3.-endoplasmic reticulum
Human-GEM MAR08235CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08236CC BY 4.0Reference data
water+MAM02931cproton+CHEBI:18132+sphing-4-enine
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalancedEC 3.1.4.12cytosol
Human-GEM MAR08246CC BY 4.0Reference data
Other names
1 name
Resolves to: sphing-4-enine
- Systematic name
- (2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-aminium