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Proteins/UNIPROT:P53985
Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition..
Function from UniProtKB (P53985), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
296 statements
296 statements · 8 reference databases · Subject: SLC16A1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
77 reactions
Transported by SLC16A1
Reaction pageReversibleBalancedEC 3.5.1.12cytosol, mitochondrial matrix
Human-GEM MAR00093CC BY 4.0Reference data
butyric acid+protonbutyric acid+proton
Transported by SLC16A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
3 names
Resolves to: SLC16A1
MAM00167cMAM00167x
Transported by SLC16A1
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR01443CC BY 4.0Reference data
proton+(S)-lactic acidproton+(S)-lactic acid
Transported by SLC16A1
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR03007CC BY 4.0Reference data
(R)-lactic acid+proton(R)-lactic acid+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR03858CC BY 4.0Reference data
proton+pyruvateproton+pyruvate
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04928CC BY 4.0Reference data
proton+pyruvateproton+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04930CC BY 4.0Reference data
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04935CC BY 4.0Reference data
acetoacetate+protonacetoacetate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04976CC BY 4.0Reference data
acetoacetate+protonacetoacetate+proton
Transported by SLC16A1
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR04977CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+proton(R)-3-hydroxybutyric acid+proton
Transported by SLC16A1
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05016CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+proton(R)-3-hydroxybutyric acid+proton
Transported by SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05018CC BY 4.0Reference data