sphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

406 compounds within 3 steps: 16 in 1, 86 in 2, 304 in 3

One step

psychosineReach from here →
1. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase
No catalyst recordedcytosol
sphingosine 1-phosphateReach from here →
1. ATP:sphingosine 1-phosphotransferase
Catalysed by DBP, SPHK2, SPHK1cytosolOne of 2 routes
N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
Catalysed by PAFAH2One of 2 routes
an N-acylsphing-4-enineReach from here →
1. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 more
sphing-4-enine 1-phosphateReach from here →
1. sphing-4-enine + ATP = sphing-4-enine 1-phosphate + ADP + H(+)
Catalysed by SPHK2, SPHK1
1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
Catalysed by PAFAH2
N-dodecanoylsphing-4-enineReach from here →
1. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by NAAA, ASAH1, ACER2, ASAH2
N-tetradecanoylsphing-4-enineReach from here →
1. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by ASAH1, ACER2, ASAH2
N-hexadecanoylsphing-4-enineReach from here →
1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by CERS6, TLCD3B, CERS5, CERS2One of 2 routes
N-octadecanoylsphing-4-enineReach from here →
1. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
Catalysed by CERS1, TLCD3B, CERS2, CERS4One of 2 routes
N-eicosanoyl-sphing-4-enineReach from here →
1. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by TLCD3B, CERS2
N-tetracosanoyl-sphing-4-enineReach from here →
1. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by CERS2
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by ACER2, ACER1, ASAH2
N-(tetracosenoyl)-sphing-4-enineReach from here →
1. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Catalysed by CERS2
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 more
sphinga-4E,14Z-dienineReach from here →
1. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by FADS3

Two steps

CHEBI:12947Reach from here →
1. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
2. UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosolOne of 5 routes
beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enineReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by ASAH1, ACER2, and 3 more

ACER1

, ASAH2

an N-acyl-sphinga-4E,14Z-dienineReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 more

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

Catalysed by PAFAH2, PLA2G15

sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by PAFAH2, PLA2G4C

2-nonadioyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by PAFAH2, PLA2G15

N-hexadecanoyl-sphinga-4E,14Z-dienineReach from here →

Catalysed by FADS3, CERS6, CERS5

cholineReach from here →

Catalysed by PAFAH2, ENPP2, GDPD3, GDPD1

hexadecanoic acidReach from here →

Catalysed by DBP, SPHK2, SPHK1, SGPL1cytosol, endoplasmic reticulumOne of 2 routes

cholesterolReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 moreOne of 9 routes

sn-glycerol 3-phosphocholineReach from here →

Catalysed by PAFAH2, PLA2G4C

O-phosphoethanolamineReach from here →

Catalysed by DBP, SPHK2, SPHK1, SGPL1cytosolOne of 2 routes

(2E)-hexadecenalReach from here →

Catalysed by DBP, SPHK2, SPHK1, SGPL1cytosolOne of 2 routes

a sphingomyelinReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 moreGolgi apparatusOne of 8 routes

a 1,2-diacyl-sn-glycerolReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 moreGolgi apparatusOne of 6 routes

dodecanoateReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2cytosolOne of 2 routes

D-glucosyl-N-acylsphingosineReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosolOne of 2 routes

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 moreOne of 2 routes

a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 moreOne of 2 routes

beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enineReach from here →

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 more

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 moreOne of 2 routes

octadecanoateReach from here →

Catalysed by CERS1, TLCD3B, CERS2, CERS4 and 3 more

elaidic acidReach from here →

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 moreGolgi apparatus

alpha-D-galactoseReach from here →

Catalysed by GALCcytosol, lysosome

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →

Catalysed by PAFAH2, PLA2G15One of 3 routes

a fatty acidReach from here →

Catalysed by CERS1, CERS6, CERS3, CERS5 and 8 more

phosphocholineReach from here →

Catalysed by PAFAH2, SMPD2

acetateReach from here →

Catalysed by PAFAH2, ASAH1

tetradecanoateReach from here →

Catalysed by ASAH1, ACER2, ASAH2

(9Z)-octadecenoateReach from here →

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 moreendoplasmic reticulumOne of 2 routes

tetracosanoateReach from here →

Catalysed by CERS2, ACER2, ACER1

eicosanoateReach from here →

Catalysed by TLCD3B, CERS2, ACER2

(15Z)-tetracosenoateReach from here →

Catalysed by ACER2, ACER1, ASAH2

1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by PAFAH2, LPCAT4