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Proteins/UNIPROT:P24557

TBXAS1

Protein·UNIPROT:P24557Thromboxane-A synthase

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Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE..

Function from UniProtKB (P24557), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

ghosal hematodiaphyseal dysplasia has a germline basis in TBXAS1DiseaseGenCC HGNC:11609|MONDO:0009274Inferred only

Statements

51 statements

51 statements · 9 reference databases · Subject: TBXAS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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TBXAS1 covaries with KCNE2ProteinHetionet hetionet:covaries:6916-9992Inferred only
TBXAS1 covaries with NAPSAProteinHetionet hetionet:covaries:6916-9476Inferred only
TBXAS1 covaries with OXER1ProteinHetionet hetionet:covaries:165140-6916Inferred only
TBXAS1 covaries with PDCD2ProteinHetionet hetionet:covaries:5134-6916Inferred only
TBXAS1 is expressed in Ammon's hornAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in bone marrowAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in granulocyteCell typeBgee ENSG00000059377Inferred only
TBXAS1 is expressed in leukocyteCell typeBgee ENSG00000059377Inferred only
TBXAS1 is expressed in lungAnatomyHuman Protein Atlas ENSG00000059377Inferred only

Show the remaining 39

TBXAS1 is expressed in lymph nodeAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in monocyteCell typeBgee ENSG00000059377Inferred only
TBXAS1 is expressed in mononuclear cellCell typeBgee ENSG00000059377Inferred only
TBXAS1 is expressed in spleenAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in testisAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000059377Inferred only
TBXAS1 interacts with UBCProteinHetionet hetionet:interacts:6916-7316Inferred only
TBXAS1 participates in Arachidonate metabolismPathwayReactome R-HSA-2142753Inferred only
TBXAS1 participates in Arachidonic acid AA ARA oxylipin metabolismPathwayWikiPathways WP5155Inferred only
TBXAS1 participates in Aspirin prevention of cancer metastasisPathwayWikiPathways WP5518Inferred only
TBXAS1 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
TBXAS1 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
TBXAS1 participates in Defective TBXAS1 causes GHDDPathwayReactome R-HSA-5579032Inferred only
TBXAS1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TBXAS1 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
TBXAS1 participates in Eicosanoid metabolism via cyclooxygenases COX PathwayWikiPathways WP4719Inferred only
TBXAS1 participates in Eicosanoid synthesisPathwayWikiPathways WP167Inferred only
TBXAS1 participates in EicosanoidsPathwayReactome R-HSA-211979Inferred only
TBXAS1 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
TBXAS1 participates in Metabolic disorders of biological oxidation enzymesPathwayReactome R-HSA-5579029Inferred only
TBXAS1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
TBXAS1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
TBXAS1 participates in Omega 3 fatty acids in senescencePathwayWikiPathways WP5432Inferred only
TBXAS1 participates in Omega 6 fatty acids in senescencePathwayWikiPathways WP5424Inferred only
TBXAS1 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
TBXAS1 participates in Prostaglandin and leukotriene metabolism in senescence PathwayWikiPathways WP5122Inferred only
TBXAS1 participates in Prostaglandin synthesis and regulationPathwayWikiPathways WP98Inferred only
TBXAS1 participates in Signaling lipidsPathwayWikiPathways WP5584Inferred only
TBXAS1 participates in Synthesis of Prostaglandins (PG) and Thromboxanes (TX)PathwayReactome R-HSA-2162123Inferred only
TBXAS1 regulates positive regulation of vasoconstrictionBiological processgene ontology P24557|GO:0045907Inferred only
TBXAS1 requires the cofactor hemeCompoundUniProt P24557Inferred only
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of TBXAS1CompoundRhea RHEA:48636Inferred only
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of TBXAS1CompoundRhea RHEA:48856Inferred only
AH2 is a substrate of TBXAS1CompoundRhea RHEA:48856Inferred only
malonaldehyde is a substrate of TBXAS1CompoundHuman-GEM MAR01339Inferred only
prostaglandin H2 is a substrate of TBXAS1CompoundHuman-GEM MAR01339Inferred only
prostaglandin H2 is a substrate of TBXAS1CompoundRhea RHEA:48644Inferred only
prostaglandin H2 is a substrate of TBXAS1CompoundRhea RHEA:17137Inferred only
prostaglandin H2 is a substrate of TBXAS1CompoundHuman-GEM MAR01313Inferred only

Reactions

7 reactions

prostaglandin H2thromboxane A2
Catalysed by TBXAS1
Reaction pageLeft to rightBalancedEC 5.3.99.5endoplasmic reticulum
Human-GEM MAR01313CC BY 4.0Reference data
MAM00308c+proton+malonaldehydeprostaglandin H2
Catalysed by TBXAS1
Reaction pageReversibleBalancedEC 5.3.99.5cytosol
Human-GEM MAR01339CC BY 4.0Reference data

Other names

7 names

Resolves to: TBXAS1

Also called: CYP5CYP5A1Cytochrome P450 5A1Hydroperoxy icosatetraenoate dehydrataseTXA synthaseTXASTXS

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prostaglandin H2

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Catalysed by TBXAS1 or CYP2S1

Reaction pageLeft to rightBalanced

Rhea RHEA:17137CC BY 4.0Reference data

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate+water

Catalysed by CYP1A1 or CYP1A2 or TBXAS1 or PTGIS or CYP1B1 or CYP2S1 or ALOXE3

Reaction pageLeft to rightBalanced

Rhea RHEA:48636CC BY 4.0Reference data

prostaglandin H2(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate+malonaldehyde

Catalysed by TBXAS1 or CYP2S1 or PTGES2

Reaction pageLeft to rightBalanced

Rhea RHEA:48644CC BY 4.0Reference data

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+AH2(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+A+water

Catalysed by TBXAS1 or PTGS2 or PTGIS

Reaction pageLeft to rightBalanced

Rhea RHEA:48856CC BY 4.0Reference data

CHEBI:59720CHEBI:131859+water

Catalysed by TBXAS1 or PTGIS or ALOXE3

Reaction pageLeft to rightBalanced

Rhea RHEA:55556CC BY 4.0Reference data