CHEBI:16633

Three steps

• an N-(fatty acyl)-glycineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, GLYATL2cytosol, mitochondrial matrix

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, GLYATL2cytosol, mitochondrial matrix

• (7Z)-octadecenoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SCLY, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 3 routes

• acetaldehydeReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SCLY, SLC7A5cytosol, extracellular spaceOne of 2 routes

• CHEBI:15345Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SCLY, AACScytosol, mitochondrial matrixOne of 2 routes

• cholineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SCLY, CHATcytosol, mitochondrial matrix, nucleusOne of 2 routes

• acetylpyruvateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SCLY, AGXT2, FAHD1cytosol, mitochondrial matrix

• all-trans-retinoic acidReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SCLY, AGXT2, SLC16A4, SLC16A5 and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SCLY, SLC7A5, TPH1, TPH2cytosol, extracellular spaceOne of 3 routes

• CHEBI:15380Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SCLY, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SCLY, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Production of Tiglylcarnitine

  Catalysed by SCLY, CPT1A, CPT1Bcytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SCLY, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SCLY, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SCLY, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SCLY, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:15519Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SCLY, ACAA1, SCP2, MYO5Bcytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SCLY, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SCLY, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Phenylacetate:CoA ligase

  Catalysed by SCLYcytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SCLY, ACSS3, ACSS2, ACSS1cytosol, mitochondrial matrixOne of 44 routes

• (S)-malateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by SCLY, AGXT2, ME2cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15611Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SCLY, AGXT, AGXT2, GNMTcytosol, mitochondrial matrix

• 10-formyltetrahydrofolic acidReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. Methionine Synthase
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by MTHFD1cytosol, nucleusOne of 3 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. Methionine Synthase
  3. histamine N-methyltransferase (SAM)

  Catalysed by HNMTcytosol, nucleus

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SCLY, SLC7A5, TPH1, TPH2cytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SCLY, ZDHHC11B, NAA10, ESCO2 and 29 morecytosol, mitochondrial matrixOne of 2 routes

• trimethylenediamineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SCLY, SLC7A6, DHPScytosol, extracellular space

• CHEBI:15727Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SCLY, NAA10cytosol, mitochondrial matrixOne of 3 routes

• CHEBI:15746Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SCLY, SAT1, SAT2cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15765Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SCLY, SLC7A5, THcytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SCLY, AGXT2, CADcytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and glutamine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SCLY, SLC3A2, SLC7A5, SLC7A10 and 2 morecytosol, extracellular space

• thioredoxin dithiolReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SCLY, AARS1cytosolOne of 2 routes

• sulfateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SCLY, SLC6A14, SLC26A6cytosol, extracellular spaceOne of 3 routes

• ureaReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and arginine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SCLY, SLC7A6, ARG1cytosol, extracellular spaceOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by SCLY, AGXT2, ABATcytosol, mitochondrial matrixOne of 3 routes

• 11-cis-retinolReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SCLY, DGAT1, LRAT, AWAT1 and 2 morecytosol, mitochondrial matrix

• cob(II)alaminReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by SCLY, MOCOS, MTRRcytosol

• iodideReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SCLY, SLC7A5, TPOcytosol, extracellular spaceOne of 25 routes

• oxaloacetateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by SCLY, AGXT2, PCcytosol, mitochondrial matrixOne of 9 routes

• nitric oxideReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and arginine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SCLY, SLC7A6, NOS3, NOS1 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:16523Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SCLY, AGXT, AGXT2, SLC3A2 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SCLY, SLC7A6, ACY1cytosol, extracellular space

• 2-phenylacetamideReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SCLY, SLC7A5, EPXcytosol, extracellular space

• anthranilateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SCLY, KYNUcytosol

• D-alanyl-D-alanineReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. alanine racemase
  3. Formation of Alanylalanine

  Catalysed by SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SCLY, SLC7A5, MARS1cytosol, extracellular space

• (S)-lactateReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SCLY, AGXT2, LDHA, LDHB and 3 morecytosol, mitochondrial matrix

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by SCLY, MOCOS, RSAD2cytosol