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Proteins/UNIPROT:Q9NUB1
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)..
Function from UniProtKB (Q9NUB1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
55 statements
55 statements · 6 reference databases · Subject: ACSS1 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
ATP+CHEBI:1146900+propionic acidAMP+diphosphate(3-)+propionyl-CoA
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.17, 6.2.1.1, 3.1.2.2cytosol
Human-GEM MAR00153CC BY 4.0Reference data
7 names
Resolves to: ACSS1
Reaction pageReversibleBalancedEC 6.2.1.1, 6.2.1.17mitochondrial matrix
Human-GEM MAR03796CC BY 4.0Reference data
ATP+CHEBI:1146900+propionic acidAMP+diphosphate(3-)+propionyl-CoA
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.17mitochondrial matrix
Human-GEM MAR03797CC BY 4.0Reference data
acetate+ATP+CHEBI:1146900CHEBI:15351+AMP+diphosphate(3-)
Reaction pageLeft to rightBalancedEC 6.2.1.1mitochondrial matrix
Human-GEM MAR04099CC BY 4.0Reference data
AMP+proton+propionyl-CoACHEBI:1146900+MAM02775c
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageReversibleBalancedEC 6.2.1.17, 6.2.1.1cytosol
Human-GEM MAR04331CC BY 4.0Reference data
ATP+proton+propionic aciddiphosphate(3-)+MAM02775c
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.1, 6.2.1.17cytosol
Human-GEM MAR04459CC BY 4.0Reference data
ATP+proton+propionic aciddiphosphate(3-)+MAM02775m
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.1, 6.2.1.17mitochondrial matrix
Human-GEM MAR04460CC BY 4.0Reference data
propanoate+ATP(4-)+coenzyme A(4-)propanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM3 or ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalanced
Rhea RHEA:20373CC BY 4.0Reference data
acetate+ATP(4-)+coenzyme A(4-)acetyl-CoA+AMP+diphosphate(3-)
Catalysed by DIP2A or ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalanced
Rhea RHEA:23176CC BY 4.0Reference data