sulfate

Three steps

• Phe-tRNA(Phe)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GARS1extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, QARS1extracellular space, cytosol

• hypoioditeReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC26A6, SLC26A4, MPO, LPOextracellular space, cytosol

• a thiolReach from here →
  1. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, NARS1extracellular space, cytosol

• phosphocholineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC26A6, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosol, peroxisomeOne of 8 routes

• cholateReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by STS, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 3 routes

• glycolateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by SLC25A10, CLYBL, GRHPRmitochondrial matrix, cytosol

• acetateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 6 routes

• CHEBI:30249Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC26A6, SLC6A14, IDO1, TDO2 and 1 moreextracellular space, cytosol

• propionic acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• butyric acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• (9Z)-octadecenoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• adipic acidReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by STS, SLC22A24, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• orotateReach from here →
  1. transport of fumarate and sulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SLC25A10, SDHB, DHODHmitochondrial matrix, cytosol

• 3-hydroxypyruvic acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, AGXTmitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SLC25A10, SDHB, SDHA, DHODHmitochondrial matrix, cytosolOne of 3 routes

• an alcoholReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, CP and 1 moreinner side of the membrane, outer side of the membrane

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A10, GOT2mitochondrial matrix, cytosol

• (9Z)-hexadecenoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• nicotinateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by SLC25A35, SLC25A34, SLC22A6, SLC22A12 and 1 moreinner side of the membrane, outer side of the membrane

• L-lysineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by SLC26A6, SLC6A14, SLC7A9, SLC25A29 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• putrescineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC26A6, SLC6A14, SLC3A2, SLC7A7extracellular space, cytosol

• 3-oxopropanoateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC25A10, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• methylarsonateReach from here →
  1. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 3 moreinner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC26A6, SLC6A14, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC26A6, SLC6A14, NDUFAB1, FDXR and 5 moreextracellular space, cytosol, mitochondrial matrix

• (24S)-hydroxycholesterolReach from here →
  1. Steryl-Sulfatase
  2. Cholesterol-sulfate sulfohydrolase
  3. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1

  Catalysed by STS, CYP46A1Golgi apparatus, cytosol, endoplasmic reticulumOne of 2 routes

• serotoninReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLC26A6, SLC12A2, SLC12A1, SLC6A4extracellular space, cytosolOne of 5 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC26A6, SLC6A14, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC26A6, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by SLC25A10, ME2, ME3, SRRmitochondrial matrix, cytosolOne of 11 routes

• an acylcholineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLC26A6, SLC5A7, BCHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC26A6, SLC6A9, SLC6A14, ALAS1 and 1 moreextracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A6, SLC6A14, BCAT1extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by STS, SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosolOne of 7 routes

• glycochenodeoxycholateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. Choloyl-CoA:glycine N-choloyltransferase

  Catalysed by SLC26A6, SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 8 routes

• taurodeoxycholateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC26A6, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• cholesteryl hexadecanoateReach from here →
  1. Steryl-Sulfatase
  2. Cholesterol-sulfate sulfohydrolase
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by STS, SOAT2, SOAT1Golgi apparatus, cytosol, endoplasmic reticulum

• 5alpha-androstane-3alpha,17beta-diolReach from here →
  1. steroid sulfatase (androsterone sulfate)
  2. steroid sulfatase (androsterone sulfate)
  3. 5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + NADH + H(+)

  Catalysed by STS, AKR1C4, AKR1C3, AKR1C2 and 1 morecytosolOne of 5 routes

• glycolithocholic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosolOne of 4 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GCATextracellular space, cytosol, mitochondrial matrix