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5alpha-androstane-3alpha,17beta-diol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

14 compounds within 3 steps: 2 in 1, 6 in 2, 6 in 3

Does it reach a compound?

One step

androsteroneReach from here →
1. 5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + NADH + H(+)
Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1
17beta-hydroxy-5alpha-androstan-3-oneReach from here →
1. 3beta-Hydroxysteroid:NADP+ oxidoreductase
Catalysed by AKR1C4cytosol

Two steps

androsterone 3alpha-sulfateReach from here →
1. 5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + NADH + H(+)
2. steroid sulfatase (androsterone sulfate)
Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1 and 1 morecytosolOne of 4 routes
5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate)Reach from here →
1. 3beta-Hydroxysteroid:NADP+ oxidoreductase
2. glucuronosyltransferase (5-alpha-dihydrotestosterone)
Catalysed by AKR1C4, UGT2B4, UGT1A1 and 2 more

Three steps

5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate]Reach from here →
Catalysed by AKR1C4, UGT2B4, UGT1A1, UGT2B28 and 2 morecytosol, endoplasmic reticulum
17beta-hydroxy-androst-5-en-3-oneReach from here →
1. 3beta-Hydroxysteroid:NADP+ oxidoreductase
2. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)

cytosol, endoplasmic reticulum

One of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by AKR1C4, STScytosolOne of 4 routes

5alpha-androstan-3,17-dioneReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)

Catalysed by AKR1C4, HSD17B2, HSD17B8, HSD17B10 and 1 morecytosolOne of 2 routes

androst-5-en-3beta,17beta-diolReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)

Catalysed by AKR1C4, HSD3B1, HSD3B2cytosolOne of 3 routes

3beta,16alpha-dihydroxy-androst-5-en-17-oneReach from here →

5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + NADH + H(+)
hydroxysteroid 17-beta dehydrogenase (androsterone)

Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1 and 1 moreendoplasmic reticulum

androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + NADH + H(+)

Catalysed by AKR1C4, HSD3B1, HSD3B2cytosol

sulfateReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
steroid sulfatase (5-alpha-dihydrotestosterone)
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by AKR1C4, STScytosolOne of 6 routes

androst-4-ene-3,17-dioneReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)
5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

Catalysed by AKR1C4, HSD17B2, HSD17B8, HSD17B10 and 2 morecytosolOne of 3 routes

3beta-hydroxy-5alpha-androstan-17-oneReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)
3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)

Catalysed by AKR1C4, HSD17B2, HSD17B8, HSD17B10 and 2 morecytosolOne of 2 routes

androst-5-en-3beta,7alpha,17beta-triolReach from here →

3beta-Hydroxysteroid:NADP+ oxidoreductase
3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)
androst-5-en-3beta,17beta-diol + reduced [NADPH--hemoprotein reductase] + O2 = androst-5-en-3beta,7alpha,17beta-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1C4, HSD3B1, HSD3B2, CYP7B1cytosol