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A reference for what the literature reports. Not medical advice.

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an alcohol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

19 compounds within 3 steps: 4 in 1, 2 in 2, 13 in 3

Does it reach a compound?

One step

an organic moleculeReach from here →
1. an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP2D7, CYP1A1, CYP1A2, CYP2E1 and 21 more
a carboxylic esterReach from here →
1. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
Catalysed by CES2, CES1, CES5A, CES3 and 1 more
a hydroperoxideReach from here →
1. a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 1 more
an alkyl sulfateReach from here →
1. an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by SULT2B1, SULT2A1, SULT1C3

Two steps

a carboxylateReach from here →
1. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
2. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
Catalysed by CES2, CES1, CES5A, CES3 and 1 more
glutathione disulfideReach from here →
1. a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 3 more

Three steps

an N-acyl-aromatic L-alpha-amino acidReach from here →
Catalysed by CES2, CES1, CES5A, CES3 and 3 more
15(S)-HPETEReach from here →

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 11 more

cytosol

L-cystineReach from here →

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
cystine to cysteine conversion

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 3 morecytosol

CHEBI:16856Reach from here →

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Glutathione: 15-HPETE oxidoreductase

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 11 morecytosolOne of 7 routes

an aldehydeReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)

Catalysed by CES2, CES1, CES5A, CES3 and 2 more

orotateReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)

Catalysed by CES2, CES1, CES5A, CES3 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

methylarsonateReach from here →

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 5 more

thiosulfateReach from here →

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 4 more

an acylcholineReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
an acylcholine + H2O = a carboxylate + choline + H(+)

Catalysed by CES2, CES1, CES5A, CES3 and 2 more

a thioesterReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a thioester + H2O = a thiol + a carboxylate + H(+)

Catalysed by CES2, CES1, CES5A, CES3 and 2 more

a 3-acylpyruvateReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by CES2, CES1, CES5A, CES3 and 2 more

glutathioneReach from here →

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

Catalysed by PRDX5, PRDX3, PRDX2, PRDX1 and 4 moreOne of 4 routes

an N-acyl-L-amino acidReach from here →

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

Catalysed by CES2, CES1, CES5A, CES3 and 3 more