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Proteins/UNIPROT:O43776
Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells..
Function from UniProtKB (O43776), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
320 statements
320 statements · 7 reference databases · Subject: NARS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
2 reactions
L-asparagine+ATP+MAM03065cAMP+Asn-tRNA(Asn)+diphosphate(3-)
Catalysed by NARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.22cytosol
Human-GEM MAR05133CC BY 4.0Reference data
CHEBI:78442+L-asparagine+ATP(4-)CHEBI:78515+AMP+diphosphate(3-)+
5 names
Resolves to: NARS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:11180CC BY 4.0Reference data