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Proteins/UNIPROT:P41252
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
Function from UniProtKB (P41252), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
164 statements
164 statements · 6 reference databases · Subject: IARS1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
ATP+L-isoleucine+MAM03072cAMP+Ile-tRNA(Ile)+diphosphate(3-)
Catalysed by IARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.5cytosol
Human-GEM MAR05140CC BY 4.0Reference data
CHEBI:78442+L-isoleucine+ATP(4-)CHEBI:78528+AMP+diphosphate(3-)
Catalysed by
4 names
Resolves to: IARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:11060CC BY 4.0Reference data