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Proteins/UNIPROT:O75908
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa..
[Isoform 2]: Has lower enzymatic activity compared to isoform 1..
[Isoform 3]: Has lower enzymatic activity compared to isoform 1..
Function from UniProtKB (O75908), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
199 statements
199 statements · 6 reference databases · Subject: SOAT2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
66 reactions
(2E)-hexadecenoyl-CoA+CHEBI:1307929MAM01505r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR02306CC BY 4.0Reference data
CHEBI:1307929+dodecanoyl-CoAMAM01498r+CHEBI:1146900
Reaction pageLeft to right
5 names
Resolves to: SOAT2
Human-GEM MAR03625CC BY 4.0Reference data
CHEBI:1307929+MAM03050rMAM01510r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03626CC BY 4.0Reference data
CHEBI:1307929+tetradecanoyl-CoAMAM01501r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03627CC BY 4.0Reference data
MAM00129r+CHEBI:1307929MAM01487r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03628CC BY 4.0Reference data
(7Z)-tetradecenoyl-CoA+CHEBI:1307929MAM01479r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03629CC BY 4.0Reference data
(5Z)-tetradecenoyl-CoA+CHEBI:1307929MAM01470r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03630CC BY 4.0Reference data
CHEBI:1307929+MAM02689rMAM01506r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03631CC BY 4.0Reference data
CHEBI:1307929+palmitoyl-CoAcholesteryl hexadecanoate+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03632CC BY 4.0Reference data
(7Z)-hexadecenoyl-CoA+CHEBI:1307929MAM01477r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03633CC BY 4.0Reference data
CHEBI:1307929+(9Z)-hexadecenoyl-CoAMAM01505r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03634CC BY 4.0Reference data
CHEBI:1307929+heptadecanoyl-CoAMAM01495r+CHEBI:1146900
Reaction pageLeft to rightBalancedEC 2.3.1.26endoplasmic reticulum
Human-GEM MAR03635CC BY 4.0Reference data