N-dodecanoylglycine

Three steps

• (7Z)-octadecenoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by GLYATL2, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 4 routes

• acetaldehydeReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosol

• CHEBI:15345Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by GLYATL2, BAAT, AACSperoxisome, cytosolOne of 2 routes

• cholineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by GLYATL2, BAAT, CHATperoxisome, nucleusOne of 2 routes

• acetylcholineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• pyruvateReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
  3. glyoxylate + L-alanine = glycine + pyruvate

  Catalysed by PAM, AGXT, AGXT2One of 20 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by GLYATL2, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GLYATL2, BAAT, ALAS1, CPNE7peroxisome, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYATL2, BAAT, GLYAT, GLYATL1peroxisome, mitochondrial matrixOne of 3 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by GLYATL2, BAAT, CPT1A, CPT1Bperoxisome, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GLYATL2, BAAT, HADHA, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GLYATL2, BAAT, GLYATperoxisome, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GLYATL2, BAAT, GLYAT, GLYATL1peroxisome, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by GLYATL2, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 12 routes

• CHEBI:15519Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by GLYATL2, BAAT, ACAA1, SCP2 and 1 moreperoxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by GLYATL2, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 13 routes

• oleoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by GLYATL2, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 12 routes

• phenylacetyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by GLYATL2, BAATperoxisome, cytosolOne of 4 routes

• propionyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GLYATL2, BAAT, ACSS3, ACSS2 and 1 moreperoxisome, cytosolOne of 43 routes

• (S)-malateReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by PAM, CLYBLOne of 2 routes

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GLYATL2, SHMT1, SHMT2One of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by GLYATL2, SHMT1, MTHFD1cytosolOne of 3 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. histamine N-methyltransferase (SAM)

  Catalysed by GLYATL2, SHMT1, HNMTcytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYATL2, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 3 routes

• CHEBI:15650Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GLYATL2, BAAT, ZDHHC11B, NAA10 and 30 moreperoxisome, cytosolOne of 6 routes

• trimethylenediamineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GLYATL2, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GLYATL2, BAAT, NAA10peroxisome, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GLYATL2, BAAT, SAT1, SAT2peroxisome, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by GLYATL2, SLC7A5, THextracellular space, cytosolOne of 5 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by GLYATL2, GNPATcytosol

• bromideReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by GLYATL2, GSS, MGST3, GSTA4 and 15 morecytosolOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by GLYATL2, SLC7A5, GFPT2, GFPT1extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. glycine:tRNA(Gly) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GLYATL2, GARS1cytosolOne of 2 routes

• phosphatidylethanolamineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by GLYATL2, LPCAT4, LPCAT3, LPCAT2 and 2 morecytosol

• a halide anionReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GLYATL2, GSS, GSTT4, GSTA4 and 21 more

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by GLYATL2, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

• sulfateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14, SLC26A6extracellular space, cytosol

• ureaReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by GLYATL2, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10 and 2 moreextracellular space, cytosolOne of 8 routes

• 11-cis-retinolReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GLYATL2, BAAT, DGAT1, LRAT and 3 moreperoxisome, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• phosphatidic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by GLYATL2, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  3. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA

  Catalysed by GLYATL2, CPT1A, CPT1C, CPT1B and 1 morecytosol

• iodideReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14, SLC26A4extracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by GLYATL2, BAAT, ACLYperoxisome, cytosol

• nitric oxideReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by GLYATL2, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GLYATL2, GATM, ACY1cytosol

• 2-phenylacetamideReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by GLYATL2, SLC7A5, EPXextracellular space, cytosol

• D-alanyl-D-alanineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of D-alanine and glycine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by GLYATL2, SLC3A2, SLC7A10extracellular space, cytosol