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Proteins/UNIPROT:Q6UWP7
Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Required for establishment of the hematopoietic and endothelial lineages (By similarity)..
Function from UniProtKB (Q6UWP7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
109 statements
109 statements · 6 reference databases · Subject: LCLAT1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
49 reactions
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51mitochondrial matrix
Human-GEM MAR00580CC BY 4.0Reference data
7 names
Resolves to: LCLAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00588CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00589CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00590CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00591CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00592CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00593CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+MAM01269cCHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00594CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-cytosol
Human-GEM MAR01088CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphate+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or MBOAT2 or LPCAT2 or LPCAT1 or ABHD5 or AGPAT1 or AGPAT4 or AGPAT3 or PNPLA3 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19709CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphate+(9Z)-octadecenoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or LCLAT1 or MBOAT2 or LPCAT2 or ABHD5 or AGPAT1 or AGPAT3 or AGPAT5
Reaction pageLeft to rightBalanced
Rhea RHEA:33187CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+coenzyme A(4-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33195CC BY 4.0Reference data