LPCAT4

Acyl-CoA-dependent lysophospholipid acyltransferase involved in phospholipid remodeling. Displays acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. Can use various medium- and long-chain, saturated and unsaturated fatty acyl-CoAs, displaying the highest activity toward unsaturated fatty acyl-CoAs. Catalysis the biosynthesis of atypical phospholipids carrying unsaturated fatty acids esterified at the sn-1 position of the glycerol backbone. Transfers unsaturated fatty acyl chains to the sn-1 position of lysophosphatidylcholines, lysophosphatidylethanolamines and lysophosphatidylserines with lysophosphatidylcholines being the preferred substrates. Contributes to the remodeling of brain phosphatidylcholine species with unsaturated fatty acyl chains such as C18:1, C18:2, C20:4 and C22:6 at the sn-1 position. Has no apparent acyltransferase activity toward lysophosphatidylinositols, lysophosphatidic acids, lysophosphatidylglycerols, glycerol-3-phosphates or diacylglycerols. Has no acetyltransferase activity toward lysoplatelet-activating factor (lyso-PAF)..

Function from UniProtKB (Q643R3), read 2026-09-23. CC BY 4.0.