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Proteins/UNIPROT:Q6ZNC8
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine. Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor. May play a role in neurite outgrowth during neuronal differentiation (By similarity)..
Function from UniProtKB (Q6ZNC8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
55 statements
55 statements · 6 reference databases · Subject: MBOAT1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
23 reactions
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51mitochondrial matrix
Human-GEM MAR00580CC BY 4.0Reference data
11 names
Resolves to: MBOAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00588CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00589CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00590CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00591CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00592CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00593CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+MAM01269cCHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00594CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Catalysed by PRDX6 or LPCAT4 or LPCAT3 or MBOAT1 or MBOAT2 or LPCAT2 or LPCAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12937CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphoethanolamine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphoethanolamine+coenzyme A(4-)
Catalysed by LPCAT4 or LPCAT3 or MBOAT1 or MBOAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32995CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phospho-L-serine+coenzyme A(4-)
Catalysed by LPCAT4 or LPCAT3 or MBOAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33191CC BY 4.0Reference data