thiosulfate

Three steps

• an alcoholReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by TSTD1, CP, PRDX6cytosol

• glutarateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by STS, SLC22A24, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A10, GOT2mitochondrial matrix, cytosol

• pentanoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• 3-oxopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. De novo synthesis of 2Fe2S

  Catalysed by CBS, NDUFAB1, FDXR, FXN and 4 morecytosol, mitochondrial matrix

• a phenolReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by ARSL, ARSF, ARSK, SULF2 and 2 morecytosol

• serotoninReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• D-serineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by MPST, TST, SRRmitochondrial matrix, cytosol

• an organic disulfideReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by SUMF1cytosol

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• glycochenodeoxycholateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• glycolithocholic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• (R)-lactic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHDmitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHB, LDHAL6Bmitochondrial matrix, cytosolOne of 5 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-iminopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by MPST, TST, RIDAmitochondrial matrix, cytosol

• phosphoenolpyruvic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by MPST, TST, PKM, PKLRmitochondrial matrix, cytosolOne of 9 routes

• N-acetyl-beta-neuraminic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by MPST, TST, NPLmitochondrial matrix, cytosol

• tert-butanolReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by TSTD1, CLIC2, GPX1, GPX2 and 2 morecytosol

• L-ornithineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC4A1, ALDH9A1cytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 12 morecytosol, extracellular space

• taurineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC26A6, SLC6A6cytosol, extracellular spaceOne of 2 routes

• a thioesterReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. a thioester + H2O = a thiol + a carboxylate + H(+)

  Catalysed by SUMF1, PNKDcytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SQOR, NQO2cytosol

• a 3-acylpyruvateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by MPST, TST, FAHD1mitochondrial matrix, cytosol

• glycineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8cytosol, extracellular spaceOne of 22 routes

• prostaglandin E1Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin H2Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX2, GPX4cytosolOne of 3 routes

• 7,8-dihydrofolateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SLC22A8, SLC22A7, DHFR, DHFR2cytosol, extracellular spaceOne of 3 routes

• leukotriene A4Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by MPST, TST, SUOXmitochondrial matrix, cytosol

• (R)-S-lactoylglutathioneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by TSTD1, GLO1cytosolOne of 3 routes

• 2-oxoadipateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• dihydroxyacetone phosphateReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by SLC25A10, SDHB, GPD2mitochondrial matrix, cytosol

• S-formylglutathioneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by TSTD1, ESDcytosolOne of 2 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• guanidinoacetateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC26A6cytosol, extracellular space

• 3',5'-cyclic GMPReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 11 routes

• adenosine 5'-phosphoramidateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by PAPSS1, PAPSS2, FHITcytosol