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Proteins/UNIPROT:P43304

GPD2

Protein·UNIPROT:P43304Glycerol-3-phosphate dehydrogenase, mitochondrial

Open in the graph

Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device..

Function from UniProtKB (P43304), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

66 statements

66 statements · 8 reference databases · Subject: GPD2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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GPD2 covaries with ZNF26ProteinHetionet hetionet:covaries:2820-7574Inferred only
GPD2 is expressed in adipose tissueAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in Ammon's hornAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in bone marrowAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in breastAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in colonAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000115159Inferred only

Show the remaining 54

GPD2 is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in epididymisAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in esophagusAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in fallopian tubeAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in liverAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in lungAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in lymph nodeAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in mouth mucosaAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in myocardiumAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in nasopharynxAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in oocyteCell typeBgee ENSG00000115159Inferred only
GPD2 is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in parathyroid glandAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in placentaAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in prostate glandAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in secondary oocyteCell typeBgee ENSG00000115159Inferred only
GPD2 is expressed in Skeletal muscle tissueAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in spermCell typeBgee ENSG00000115159Inferred only
GPD2 is expressed in spleenAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in stomachAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in testisAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in urinary bladderAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in uterine cervixAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in vaginaAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000115159Inferred only
GPD2 interacts with UBCProteinHetionet hetionet:interacts:2820-7316Inferred only
GPD2 participates in Fatty acid beta oxidationPathwayWikiPathways WP143Inferred only
GPD2 participates in Glycerol metabolism including linked IMDsPathwayWikiPathways WP5570Inferred only
GPD2 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
GPD2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPD2 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GPD2 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
GPD2 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
GPD2 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
GPD2 participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
GPD2 participates in Triglyceride catabolismPathwayReactome R-HSA-163560Inferred only
GPD2 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
HSF1 decreases the expression of GPD2ProteinHetionet hetionet:regulates:3297-2820Inferred only
MRPS16 increases the expression of GPD2ProteinHetionet hetionet:regulates:51021-2820Inferred only
POLD1 increases the expression of GPD2ProteinHetionet hetionet:regulates:5424-2820Inferred only
GPD2 requires the cofactor FAD(3-)CompoundUniProt P43304Inferred only
a quinone is a substrate of GPD2CompoundRhea RHEA:18977Inferred only
CHEBI:15978 is a substrate of GPD2CompoundHuman-GEM MAR00449Inferred only
CHEBI:15978 is a substrate of GPD2CompoundHuman-GEM MAR01169Inferred only
sn-glycerol 3-phosphate is a substrate of GPD2CompoundRhea RHEA:18977Inferred only
ubiquinol is a substrate of GPD2CompoundHuman-GEM MAR06911Inferred only
ubiquinones is a substrate of GPD2CompoundHuman-GEM MAR06911Inferred only

Reactions

4 reactions

FAD+CHEBI:15978CHEBI:16108+FADH2
Catalysed by GPD2
Reaction pageLeft to rightBalancedEC 1.1.5.3mitochondrial matrix
Human-GEM MAR00449CC BY 4.0Reference data
FAD+CHEBI:15978CHEBI:16108+FADH2
Catalysed by GPD2
Reaction pageLeft to rightBalancedEC 1.1.5.3mitochondrial matrix, cytosol
Human-GEM MAR01169

Other names

5 names

Resolves to: GPD2

Also called: GPD-MGPDH-MmGDHmitochondrial glycerophosphate dehydrogenase genemtGPD

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CC BY 4.0

Reference data

FADH2+ubiquinonesFAD+ubiquinol

Catalysed by CHDH or PRODH or DHODH or ETFB or GPD2 or SQOR or ETFA or ETFDH or PRODH2

Reaction pageReversibleBalancedEC 1.5.5.1mitochondrial matrix

Human-GEM MAR06911CC BY 4.0Reference data

a quinone+sn-glycerol 3-phosphatedihydroxyacetone phosphate+a quinol

Catalysed by GPD2

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:18977CC BY 4.0Reference data