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Proteins/UNIPROT:Q8IWU5

SULF2

Protein·UNIPROT:Q8IWU5Extracellular sulfatase Sulf-2

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Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin..

Function from UniProtKB (Q8IWU5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

40 statements

40 statements · 5 reference databases · Subject: SULF2 · Sources: Bgee, gene ontology, Hetionet, Rhea, UniProt

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SULF2 is expressed in adenohypophysisAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in body of uterusAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in calcaneal tendonAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in cardiac muscle of right atriumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in deciduaAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in endocervixAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in endometriumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in esophagusAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in esophagus mucosaAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in female reproductive systemAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in gallbladderAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in granulocyteCell typeBgee ENSG00000196562Inferred only

Show the remaining 28

SULF2 is expressed in layer of synovial tissueAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in left fallopian tubeAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in left ovaryAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in leukocyteCell typeBgee ENSG00000196562Inferred only
SULF2 is expressed in monocyteCell typeBgee ENSG00000196562Inferred only
SULF2 is expressed in myometriumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in ovaryAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in pericardiumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in peritoneumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in rectumAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in right fallopian tubeAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in right ovaryAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in smooth muscle tissueAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in synovial jointAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in tendonAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in tendon of biceps brachiiAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in uterine cervixAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in uterusAnatomyBgee ENSG00000196562Inferred only
SULF2 is expressed in vermiform appendixAnatomyBgee ENSG00000196562Inferred only
UBC interacts with SULF2ProteinHetionet hetionet:interacts:55959-7316Inferred only
SULF2 regulates negative regulation of fibroblast growth factor receptor signaling pathwayBiological processgene ontology Q8IWU5|GO:0040037Inferred only
SULF2 regulates positive regulation of endothelin productionBiological processgene ontology Q8IWU5|GO:1904472Inferred only
SULF2 regulates positive regulation of vascular endothelial growth factor productionBiological processgene ontology Q8IWU5|GO:0010575Inferred only
SULF2 regulates positive regulation of Wnt signaling pathwayBiological processgene ontology Q8IWU5|GO:0030177Inferred only
SULF2 requires the cofactor Ca(2+)CompoundUniProt Q8IWU5Inferred only
a phenol is a substrate of SULF2CompoundRhea RHEA:17261Inferred only
an aryl sulfate is a substrate of SULF2CompoundRhea RHEA:17261Inferred only
sulfate is a substrate of SULF2CompoundRhea RHEA:17261Inferred only

Reactions

1 reaction

an aryl sulfate+watera phenol+sulfate+hydron
Catalysed by ARSL or ARSF or ARSK or SULF2 or SULF1 or ARSG
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17261CC BY 4.0Reference data

Other names

5 names

Resolves to: SULF2

Also called: [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]ArylsulfatasehSulf-2KIAA1247N-acetylglucosamine-6-sulfatase

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