malonic acid

Three steps

• CHEBI:16633Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC6A14, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC6A14, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC25A10, MPST, TST, LDHA and 4 moremitochondrial matrix, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC6A14, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC6A14, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• tryptamineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC6A14, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A10, MPST, TST, KYAT1mitochondrial matrix, cytosolOne of 5 routes

• 3-fumarylpyruvateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC25A10, FAHD1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16856Reach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. Persulfide dioxygenase

  Catalysed by SLC25A10, ETHE1mitochondrial matrix, cytosolOne of 3 routes

• glyoxylic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC6A9, SLC6A14, DAOextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GAMTextracellular space, cytosolOne of 2 routes

• N-acetyl-L-aspartateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC25A10, SLC25A14, SLC25A30, NAT8Lmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• taurolithocholateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by SLC25A10, MPST, TST, AGXTmitochondrial matrix, cytosol

• estroneReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A10, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• aceneuramateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by SLC25A10, MPST, TST, NPLmitochondrial matrix, cytosol

• 5'-deoxyadenosineReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A10, MPST, TST, TYW1B and 1 moremitochondrial matrix, cytosol

• linoleic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• D-aspartic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 3 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC6A14, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Proline by the Apical Imino Amino Acid Transporters
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by CLTRN, SLC6A20, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC6A14extracellular space, cytosol, mitochondrial matrix

• enol-oxaloacetateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A10, SDHB, SDHAmitochondrial matrix, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLC6A14, CPT2, CPT1Aextracellular space, cytosol, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SLC6A6, MTO1extracellular space, cytosolOne of 6 routes

• 5-aminolevulinic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC6A9, SLC6A14, ALAS1, ALAS2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• diiodineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLC26A4, TPOextracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC6A14, IL4I1extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 3 routes

• CHEBI:17724Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of betaine and chloride (cytosol to extracellular)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC6A12, BHMT, BHMT2extracellular space, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC6A14, AARS1extracellular space, cytosol

• trans-urocanateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC6A14, HALextracellular space, cytosol

• urateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC6A14, TPH1, TPH2extracellular space, cytosol

• methylarsonous acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLC25A10, TSTD1, GSTO1, GSTO2mitochondrial matrix, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC6A14, SLC3A2, SLC7A6extracellular space, cytosol

• 3-oxopropanoic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A6, SLC6A14, ABATextracellular space, cytosol, mitochondrial matrix

• butanoateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC25A10, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC6A14, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• thiocyanateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A10, SLC25A14, SLC25A30, SLC26A1 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• 4-fumarylacetoacetateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A10, FAHmitochondrial matrix, cytosol

• dTDPReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A10, MPST, TST, PKM and 1 moremitochondrial matrix, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC5A7, CHKA, CHKBextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosol

• arsenic triglutathioneReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by SLC25A10, TSTD1, AS3MTmitochondrial matrix, cytosolOne of 3 routes