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Proteins/UNIPROT:O43772
Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange)..
Function from UniProtKB (O43772), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
152 statements
152 statements · 5 reference databases · Subject: SLC25A20 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
106 reactions
O-acetyl-(R)-carnitineO-acetyl-(R)-carnitine
Transported by SLC25A20
Reaction pageReversibleBalancedEC 3.1.3.2cytosol, mitochondrial matrix
Human-GEM MAR00060CC BY 4.0Reference data
MAM02636cMAM02636m
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00064CC BY 4.0Reference data
MAM01772cMAM01772m
Transported by SLC25A20
4 names
Resolves to: SLC25A20
Human-GEM MAR00076CC BY 4.0Reference data
O-hexadecanoyl-(R)-carnitineO-hexadecanoyl-(R)-carnitine
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00102CC BY 4.0Reference data
MAM02117cMAM02117m
Transported by SLC25A20
Reaction pageReversibleBalancedEC 2.3.1.21cytosol, mitochondrial matrix
Human-GEM MAR00105CC BY 4.0Reference data
MAM02676cMAM02676m
Transported by SLC25A20
Reaction pageReversibleBalancedEC 2.3.1.21cytosol, mitochondrial matrix
Human-GEM MAR00106CC BY 4.0Reference data
MAM02940cMAM02940m
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00107CC BY 4.0Reference data
MAM02639cMAM02639m
Transported by SLC25A20
Reaction pageReversibleBalancedEC 2.3.1.21cytosol, mitochondrial matrix
Human-GEM MAR00110CC BY 4.0Reference data
MAM01363cMAM01363m
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00111CC BY 4.0Reference data
MAM00120cMAM00120m
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00128CC BY 4.0Reference data
MAM00092cMAM00092m
Transported by SLC25A20
Reaction pageReversibleBalancedEC 3.5.4.12cytosol, mitochondrial matrix
Human-GEM MAR00143CC BY 4.0Reference data
(S)-carnitine+MAM02635m(S)-carnitine+MAM02635c
Transported by SLC25A20
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00160CC BY 4.0Reference data