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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q9HBJ8

CLTRN

Protein·UNIPROT:Q9HBJ81 compound

Open in the graph

Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function. Stimulator of beta cell replication..

Function from UniProtKB (Q9HBJ8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

sodium(1+)ElementCHEBI:29101Inferred only16 paths1 endpoint

What the reference databases state

GenCC submitters' classifications

1 row

Hartnup disease has a germline basis in CLTRNDiseaseGenCC HGNC:29437|MONDO:0009324Inferred only

Statements

56 statements

56 statements · 5 reference databases · Subject: CLTRN · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways

Search this listOrder

CLTRN covaries with COXFA4L3ProteinHetionet hetionet:covaries:57393-84419Inferred only
CLTRN interacts with RBM18ProteinHetionet hetionet:interacts:57393-92400Inferred only
CLTRN participates in Amino acid transport defects IEMs PathwayWikiPathways WP5029Inferred only
CLTRN participates in Insulin processingPathwayReactome R-HSA-264876Inferred only
CLTRN participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CLTRN participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
CLTRN participates in Proximal tubule transportPathwayWikiPathways WP4917Inferred only
CLTRN regulates positive regulation of amino acid transportBiological processgene ontology Q9HBJ8|GO:0051957Inferred only
CLTRN regulates positive regulation of L-proline import across plasma membraneBiological processgene ontology Q9HBJ8|GO:1905737Inferred only
CHEBI:17203 is transported by CLTRNCompoundHuman-GEM MAR07194Inferred only
CHEBI:17895 is transported by CLTRNCompoundHuman-GEM MAR09908Inferred only
CHEBI:18095 is transported by CLTRNCompoundHuman-GEM MAR06860Inferred only

Show the remaining 44

chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09907Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09904Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09898Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09895Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR06860Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09892Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09876Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09909Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09908Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR07194Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09869Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09891Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09871Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09872Inferred only
chlorine(.) is transported by CLTRNCompoundHuman-GEM MAR09888Inferred only
L-alanine is transported by CLTRNCompoundHuman-GEM MAR09869Inferred only
L-arginine is transported by CLTRNCompoundHuman-GEM MAR09871Inferred only
L-asparagine is transported by CLTRNCompoundHuman-GEM MAR09872Inferred only
L-cysteine is transported by CLTRNCompoundHuman-GEM MAR09876Inferred only
L-glutamate(1-) is transported by CLTRNCompoundHuman-GEM MAR09888Inferred only
L-isoleucine is transported by CLTRNCompoundHuman-GEM MAR09891Inferred only
L-leucine is transported by CLTRNCompoundHuman-GEM MAR09892Inferred only
L-methionine is transported by CLTRNCompoundHuman-GEM MAR09895Inferred only
L-phenylalanine is transported by CLTRNCompoundHuman-GEM MAR09898Inferred only
L-seryl residue is transported by CLTRNCompoundHuman-GEM MAR09904Inferred only
L-tryptophan is transported by CLTRNCompoundHuman-GEM MAR09907Inferred only
L-valine is transported by CLTRNCompoundHuman-GEM MAR09909Inferred only
selenomethionine is transported by CLTRNCompoundHuman-GEM MAR11791Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09869Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR07194Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09891Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR06860Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09892Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09895Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09898Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09876Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09872Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09871Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09888Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09904Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09907Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09908Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR09909Inferred only
sodium(1+) is transported by CLTRNCompoundHuman-GEM MAR11791Inferred only

Reactions

16 reactions

chlorine(.)+2sodium(1+)+CHEBI:18095chlorine(.)+2sodium(1+)+CHEBI:18095
Transported by CLTRN & SLC6A20
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06860CC BY 4.0Reference data
chlorine(.)+2sodium(1+)+CHEBI:17203chlorine(.)

Other names

3 names

Resolves to: CLTRN

Also called: CollectrinTMEM27Transmembrane protein 27

← Every protein Find it in the graph →

+

Transported by CLTRN & SLC6A20

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR07194CC BY 4.0Reference data

L-alanine+chlorine(.)+sodium(1+)L-alanine+chlorine(.)+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09869CC BY 4.0Reference data

L-arginine+chlorine(.)+sodium(1+)L-arginine+chlorine(.)+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09871CC BY 4.0Reference data

L-asparagine+chlorine(.)+sodium(1+)L-asparagine+chlorine(.)+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09872CC BY 4.0Reference data

chlorine(.)+L-cysteine+sodium(1+)chlorine(.)+L-cysteine+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09876CC BY 4.0Reference data

chlorine(.)+L-glutamate(1-)+sodium(1+)chlorine(.)+L-glutamate(1-)+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09888CC BY 4.0Reference data

chlorine(.)+L-isoleucine+sodium(1+)chlorine(.)+L-isoleucine+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09891CC BY 4.0Reference data

chlorine(.)+L-leucine+sodium(1+)chlorine(.)+L-leucine+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09892CC BY 4.0Reference data

chlorine(.)+L-methionine+sodium(1+)chlorine(.)+L-methionine+sodium(1+)

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09895CC BY 4.0Reference data

chlorine(.)+sodium(1+)+L-phenylalaninechlorine(.)+sodium(1+)+L-phenylalanine

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09898CC BY 4.0Reference data

chlorine(.)+sodium(1+)+L-seryl residuechlorine(.)+sodium(1+)+L-seryl residue

Transported by SLC6A18 & CLTRN

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09904CC BY 4.0Reference data

Show the remaining 4