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Proteins/UNIPROT:Q9HBK9
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH..
Function from UniProtKB (Q9HBK9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 7 reference databases · Subject: AS3MT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
MAM01367c+S-adenosyl-L-methionineproton+methylarsonate+CHEBI:16680
Catalysed by AS3MT
Reaction pageReversibleBalancedEC 2.1.1.137cytosol
Human-GEM MAR09525CC BY 4.0Reference data
arsenic triglutathione+3[thioredoxin]-dithiol+3S-adenosyl-L-methioninetrimethylarsine+3[thioredoxin]-disulfide+3
3 names
Resolves to: AS3MT
Catalysed by AS3MT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69432CC BY 4.0Reference data
arsenic triglutathione+[thioredoxin]-dithiol+S-adenosyl-L-methionine+2watermethylarsonous acid+[thioredoxin]-disulfide+3glutathione+S-adenosyl-L-homocysteine+hydron
Catalysed by AS3MT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69460CC BY 4.0Reference data
arsenic triglutathione+2[thioredoxin]-dithiol+2S-adenosyl-L-methionine+waterdimethylarsinous acid+2[thioredoxin]-disulfide+3glutathione+2S-adenosyl-L-homocysteine+2hydron
Catalysed by AS3MT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69464CC BY 4.0Reference data