Compound
estrone
No description recorded for this entry yet. Everything this graph holds about estrone is below.
CHEBI:17263ChEBI
Structure
- Class
- Organic compound
- Formula
- C18H22O2
- Mass
- 270.372 g/mol
- Charge
- 0
- InChIKey
- DNXHEGUUPJUMQT-CBZIJGRNSA-N
- SMILES
- [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What it touches on the way
A finding says estrone moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
31 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
31 entities
31 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hops31 assembled from the scaffold
- CYP1A1ProteinUNIPROT:P04798metabolized byInferred only152 paths32 endpoints
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only144 paths48 endpoints
- CYP19A1ProteinUNIPROT:P11511metabolized byInferred only100 paths25 endpoints
- CYP1A2ProteinUNIPROT:P05177metabolized byInferred only76 paths38 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only62 paths31 endpoints
- CYP1B1ProteinUNIPROT:Q16678metabolized byInferred only58 paths29 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only46 paths23 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only42 paths21 endpoints
- CYP3A7ProteinUNIPROT:P24462metabolized byInferred only39 paths13 endpoints
- CYP2C9ProteinUNIPROT:P11712metabolized byInferred only35 paths35 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only32 paths16 endpoints
- HSD17B1ProteinUNIPROT:P14061substrate ofInferred only30 paths15 endpoints
Show the remaining 19
- CYP3A5ProteinUNIPROT:P20815metabolized byInferred only30 paths15 endpoints
- CYP2C8ProteinUNIPROT:P10632metabolized byInferred only29 paths29 endpoints
- HSD17B12ProteinUNIPROT:Q53GQ0substrate ofInferred only24 paths12 endpoints
- CYP2B6ProteinUNIPROT:P20813metabolized byInferred only20 paths20 endpoints
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only17 paths17 endpoints
- HSD17B3ProteinUNIPROT:P37058substrate ofInferred only16 paths16 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only15 paths15 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only14 paths14 endpoints
- STSProteinUNIPROT:P08842substrate ofInferred only13 paths13 endpoints
- SULT1E1ProteinUNIPROT:P49888metabolized byInferred only13 paths13 endpoints
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only13 paths13 endpoints
- HSD17B2ProteinUNIPROT:P37059substrate ofInferred only12 paths12 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only11 paths11 endpoints
- HSD17B11ProteinUNIPROT:Q8NBQ5substrate ofInferred only10 paths5 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only8 paths4 endpoints
- AKR1B15ProteinUNIPROT:C9JRZ8substrate ofInferred only5 paths5 endpoints
- HSD17B8ProteinUNIPROT:Q92506substrate ofInferred only5 paths5 endpoints
- HSD17B13ProteinUNIPROT:Q7Z5P4substrate ofInferred only3 paths3 endpoints
- DHRS11ProteinUNIPROT:Q6UWP2substrate ofInferred only1 path1 endpoint
What the reference databases state
The section above shows paths a projection assembled. This is the reference layer itself, one step from estrone: what the cleared databases state it reacts with, is carried by, is converted to and takes part in, whether or not a projection has walked it yet.
Regulatory determinations
Published numbers and scores, transcribed from the body that issued them. A determination is not a finding and is not graded; it is the number, who set it, and the document it came from.
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Dimethyl Fumarate". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
60 statements
60 statements in 2 reference databases name estrone — Human-GEM, Rhea. Press a relation to see only its rows; every count is the rows behind it.
- estrone is converted to 17alpha-estradiolCompoundRhea RHEA:16705Inferred only
- 17alpha-estradiol is converted to estroneCompoundRhea RHEA:16705Inferred only
- 17beta-estradiol is converted to estroneCompoundRhea RHEA:24616Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24616Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24612Inferred only
- 17beta-estradiol is converted to estroneCompoundRhea RHEA:24612Inferred only
- estrone is metabolised by CYP19A1ProteinRhea RHEA:38195Inferred only
- estrone is metabolised by CYP19A1ProteinHuman-GEM MAR07940Inferred only
- estrone is metabolised by CYP19A1ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP19A1ProteinRhea RHEA:38207Inferred only
- estrone is metabolised by CYP1A1ProteinRhea RHEA:47312Inferred only
- estrone is metabolised by CYP1A1ProteinRhea RHEA:47204Inferred only
Show the remaining 48
- estrone is metabolised by CYP1A1ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP1A1ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by CYP1A1ProteinRhea RHEA:47308Inferred only
- estrone is metabolised by CYP1A2ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP1A2ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by CYP1B1ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by CYP1B1ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP2B6ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP2C8ProteinRhea RHEA:47204Inferred only
- estrone is metabolised by CYP2C9ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP3A4ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by CYP3A4ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP3A4ProteinRhea RHEA:47204Inferred only
- estrone is metabolised by CYP3A5ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP3A5ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by CYP3A7ProteinRhea RHEA:47208Inferred only
- estrone is metabolised by CYP3A7ProteinRhea RHEA:47204Inferred only
- estrone is metabolised by CYP3A7ProteinRhea RHEA:47292Inferred only
- estrone is metabolised by SULT1E1ProteinRhea RHEA:15973Inferred only
- estrone is metabolised by UGT1A10ProteinRhea RHEA:52476Inferred only
- estrone is metabolised by UGT1A3ProteinRhea RHEA:52476Inferred only
- estrone is metabolised by UGT1A8ProteinRhea RHEA:52476Inferred only
- estrone is a substrate of AKR1B15ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of AKR1C1ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of AKR1C1ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of AKR1C2ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of AKR1C2ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of AKR1C3ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of AKR1C3ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of AKR1C4ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of AKR1C4ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of DHRS1ProteinRhea RHEA:16705Inferred only
- estrone is a substrate of DHRS11ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B1ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B1ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B10ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B11ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B11ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B12ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B12ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B13ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B2ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B3ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B6ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B6ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of HSD17B7ProteinRhea RHEA:24616Inferred only
- estrone is a substrate of HSD17B8ProteinRhea RHEA:24612Inferred only
- estrone is a substrate of STSProteinRhea RHEA:31055Inferred only
Other names
7 names
Every name this graph resolves to estrone. Searching any of them lands here.
- Also called
- 3-Hydroxy-1,3,5(10)-estratrien-17-one3-hydroxy-estra-1,3,5(10)-trien-17-onefollicular hormonefolliculinoestroneST 18:4;O2
- Systematic name
- 3-hydroxyestra-1,3,5(10)-trien-17-one